| Project/Area Number |
15K18895
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Natural medicines
|
|---|
| Research Institution | Fukuoka University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 腸内細菌 / 薬物代謝 / 天然物 / 肝保護 / 代謝 / 天然化合物 |
|---|
| Outline of Final Research Achievements |
Many glycosides were isolated from natural medicines and wild grasses that have eating experiences, such as wild vegetables, and these compounds were studied for metabolism using human intestinal bacterial strains and human intestinal flora. In addition, hepatoprotective activity was evaluated for compounds obtained from these natural products and their metabolites. It turned out that all separated glycosides were metabolized. Through these metabolic experiments, the metabolic rate of each was also found out. As a result of measurement of hepatoprotective activity, significant increase in activity was confirmed in the final metabolites quercetin and Kaempferol. It was suggested that metabolism by intestinal bacteria affects activation of activity.
|
