| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Ertredin is a compound found by searching for anchorage-independent cell proliferation inhibitor using NIH 3T3 cells. There was still room for improvement in the activity and physical properties of Ertredin. Therefore, I focused on this research project.
By the structure-activity relationship study of Ertredin, I revealed the functional group which plays an important role in activity expression. Form those results, I found new compounds having stronger activity than Ertredin. It also was showed activity in the new evaluation system to which human alveolar basal epithelial adenocarcinoma cell A549 was added. Also, these compounds acted on the mitochondrial respiratory chain complex I.
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