Quinones-mediated activation of aromatic hydrocarbon receptor through its chemical modification
| Project/Area Number |
15K18906
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ABIKO Yumi 筑波大学, 医学医療系, 助教 (80742866)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 親電子物質 / 芳香族炭化水素受容体 / チオール基 / キノン体 / 大気汚染物質 / シグナル伝達 / 環境毒性学 |
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| Outline of Final Research Achievements |
Exposure of cells to electrophilic mono- and bi-cyclic quinones, but not aromatic hydrocarbons (Ahs, parent compounds of electrophiles) and quinones without covalent binding capability, to Hepa1c1c7 cells upregulated CYP1A1 through activation of aromatic hydrocarbon receptor (AhR). These findings suggest that induction of phase-I enzymes regulated by AhR by environmental electrophiles such as mono- and bi-cyclic quinones is a health risk of environmental chemicals exposure.
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Report
(3 results)
Research Products
(8 results)
