Comprehensive evaluation of recreational drugs and their impurity toxicity according to actual abuse situation
Project/Area Number |
15K18908
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Environmental and hygienic pharmacy
|
Research Institution | Showa University |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 危険ドラッグ / 合成カンナビノイド / 合成カチノン / 吸入曝露 / 熱分解物 / 興奮作用 / 依存性 / alpha-PVP / UR-144 |
Outline of Final Research Achievements |
Drug abusers most often smoke ‘herbal incense’ as a cigarette or inhale it using a smoking tool. In order to clarify the biological effect of inhalation, we developed the recreational drug-inhalation system for small animals. It was revealed that some kind of synthetic cannabinoids (SC) such as UR-144 generates thermal decomposition by heating at the time of inhalation and shows an excitatory action at the beginning after inhalation. In addition, the thermal decomposition revealed that CB 1 receptor activity is stronger than that of the parent compound. We also examined the excitatory mechanism. In addition, we investigated the dependence of SC and synthetic cathinone on single component and concomitant use, and revealed that alpha-PVP stimulates the reward pathway by increasing the extracellular dopamine levels and CREB phosphorylation in the nucleus accumbens shell, eventually causing positive reinforcement.
|
Report
(3 results)
Research Products
(20 results)
-
-
[Journal Article] Three 25-NBOMe-type drugs, three other phenethylamine-type drugs (25I-NBMD, RH34 and escaline), eight cathinone derivatives and a phencyclidine analog MMXE, newly identified in ingredients of drug products before they were sold on the drug market.2016
Author(s)
Kaizaki-Mitsumoto A, Noguchi N, Yamaguchi S, Odanaka Y, Matsubayashi S, Kumamoto H, Fukuhara K, Funada M, Wada K, Numazawa S.
-
Journal Title
Forensic Toxicol
Volume: 34
Issue: 1
Pages: 108-114
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
[Presentation] 血液透析が奏功した急性カフェイン中毒の2例2016
Author(s)
宮本和幸, 丸田雄一, 高安弘美, 渡邊円香, 光本明日香, 田中広紀, 向後麻里, 佐々木純, 沼沢聡, 林宗貴
Organizer
第38回日本中毒学会総会・学術集会
Place of Presentation
朱鷺メッセ(新潟)
Year and Date
2016-07-23
Related Report
-
-
-
-
-
-
-
-
-
-
-