| Project/Area Number |
15K18910
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
Fujiki Kota 東京女子医科大学, 医学部, 助教 (80632504)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 重金属ストレス応答 / シグナル伝達 / 肺癌 / 上皮間葉転移 / 薬学 / 衛生学 / カドミウム / 悪性化 / Notch1 |
|---|
| Outline of Final Research Achievements |
Cadmium exposure is known to increase lung cancer risk, but the underlying molecular mechanisms in cadmium-stimulated progression of malignancy are unclear. Here, we examined the effects of prolonged cadmium exposure on the malignant progression of A549 human lung adenocarcinoma cells and the roles of Notch1, HIF-1α, and PI3K/Akt/ERK signaling pathways. As a result, we found that Notch1, along with HIF-1α and PI3K/Akt/ERK signaling pathways, promotes malignant progression stimulated by prolonged cadmium exposure in A549 cells.
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