Development and assessment for the treatment for oral mucositis caused by chemo- and radiotherapy in cancer patients
| Project/Area Number |
15K18916
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Teikyo Heisei University (2016-2017)
University of Tsukuba (2015) |
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Principal Investigator |
MOMO Kenji 帝京平成大学, 薬学部, 准教授 (30645552)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 口腔粘膜炎 / がん化学療法 / 放射線療法 / インドメタシンスプレー / 院内製剤 / 臨床製剤 / インドメタシン噴霧製剤 / インドメタシン / 化学療法 / 頭頚部がん / 血液がん |
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| Outline of Final Research Achievements |
In this study, we clarified a treatment strategy for oral mucositis caused by chemo- and radio-therapy in cancer patients. Briefly, we used the 0.25% of indomethacin solution to the mucositis in the oral cavity of 28 cancer patients with oral mucositis. The pain relief was obtained 26 out of 28 (93%) in this study. The absorption of indomethacin after applying indomethacin oral spray in 7 cancer patients was found comparable to the topical indomethacin agents such as patch or lotion. In conclution, we found the indometahcin oral spray was safe and effective in the patients with oral mucositis.
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Report
(4 results)
Research Products
(6 results)
