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Development and assessment for the treatment for oral mucositis caused by chemo- and radiotherapy in cancer patients

Research Project

Project/Area Number 15K18916
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionTeikyo Heisei University (2016-2017)
University of Tsukuba (2015)

Principal Investigator

MOMO Kenji  帝京平成大学, 薬学部, 准教授 (30645552)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords口腔粘膜炎 / がん化学療法 / 放射線療法 / インドメタシンスプレー / 院内製剤 / 臨床製剤 / インドメタシン噴霧製剤 / インドメタシン / 化学療法 / 頭頚部がん / 血液がん
Outline of Final Research Achievements

In this study, we clarified a treatment strategy for oral mucositis caused by chemo- and radio-therapy in cancer patients. Briefly, we used the 0.25% of indomethacin solution to the mucositis in the oral cavity of 28 cancer patients with oral mucositis. The pain relief was obtained 26 out of 28 (93%) in this study. The absorption of indomethacin after applying indomethacin oral spray in 7 cancer patients was found comparable to the topical indomethacin agents such as patch or lotion. In conclution, we found the indometahcin oral spray was safe and effective in the patients with oral mucositis.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy.2017

    • Author(s)
      Momo K, Nagaoka H, Kizawa Y, Bukawa H, Chiba S, Kohda Y, Homma M
    • Journal Title

      Support Care Cancer.

      Volume: 25 Issue: 10 Pages: 2997-3000

    • DOI

      10.1007/s00520-017-3817-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Indomethacin Spray Preparation for the Control of Pain Associated with Stomatitis Caused by Chemotherapy and Radiotherapy in Cancer Patients2015

    • Author(s)
      Momo K
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 135 Issue: 8 Pages: 931-935

    • DOI

      10.1248/yakushi.15-00112-1

    • NAID

      130005089835

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2015-08-01
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 院内製剤の臨床使用に関する情報の実態調査2017

    • Author(s)
      百賢二
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2017-03-25
    • Related Report
      2016 Research-status Report
  • [Presentation] Assessment of indomethacin oral spray for the treatment of anticancer therapy induced severe oral and oropharyngeal mucositis.2017

    • Author(s)
      MomoK
    • Organizer
      7th International Conference and Expo on cosmetology, trichology & aesthetic practices
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] がん治療成績の向上を目指した院内製剤の臨床応用と新規開発シーズの探索2017

    • Author(s)
      百 賢二
    • Organizer
      製剤機械技術学会 第27回大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 化学・放射線療法誘発性の口腔粘膜炎に対するインドメタシンスプレーの臨床効果2016

    • Author(s)
      百賢二
    • Organizer
      第10回日本緩和医療薬学会
    • Place of Presentation
      アクトシティ浜松(静岡県・浜松市)
    • Year and Date
      2016-06-04
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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