Involvement of nutrient composition and intestinal flora on regulation factors of pharmacokinetics

• Project/Area Number: 15K18918
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Kanazawa University
• Principal Investigator: Shimada Tsutomu 金沢大学, 附属病院, 准教授 (90409384)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 薬物動態変動要因 / 栄養環境 / 腸内細菌叢 / 腸内細菌 / プロバイオティクス / プレバイオティクス / 体内動態変動 / 薬物動態 / 食物繊維 / 整腸剤 / 高脂肪食

Outline of Final Research Achievements

Absence of intestinal flora Affect pharmacokinetics of drug, however there was no report whether regulation of intestinal flora by daily life affect drug safe and effective.
This study investigated the effects of increment of good bacteria in intestine using the animal model treated dietary fiber and medicine for intestinal disorders. The results showed that water soluble dietary fiber and medicine for intestinal disorders, which increase good bacteria, did not significantly affect pharmacokinetics factors. This study suggested that regulation of intestinal flora in dairy life would not affect pharmacokinetics of drugs.