Significant factors associated with the decrease in CYP3A activity in patients with chronic renal failure
Project/Area Number |
15K18926
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Medical pharmacy
|
Research Institution | Oita University |
Principal Investigator |
Suzuki Yosuke 大分大学, 医学部, 薬物動態解析室主任 (10737191)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | CYP3A / 慢性腎不全 / Phenoconversion / 3-indoxyl sulfate / CYP3A5 / 腎移植 / 代謝 / 薬物動態 |
Outline of Final Research Achievements |
The aim of this study was to identify significant factors associated with the decrease in CYP3A activity in patients with chronic renal failure. Compared with before kidney transplantation, plasma 4β-hydroxycholesterol concentrations were significantly elevated on days 90 and 180 after living kidney transplantation. Plasma concentrations of 4β-hydroxycholesterol on days 90 and 180 after kidney transplantation were significantly higher in the presence of the CYP3A5*1 allele than in the absence of the CYP3A5*1 allele. Furthermore, accumulation of indoxyl sulfate was associated with phenoconversion of CYP3A in stable kidney transplant recipients.
|
Report
(3 results)
Research Products
(6 results)
-
[Journal Article] CYP3A5 polymorphism affects the increase in CYP3A activity after living kidney transplantation in patients with end stage renal disease.2015
Author(s)
Suzuki Y, Fujioka T, Sato F, Matsumoto K, Muraya N, Tanaka R, Sato Y, Ohno K, Mimata H, Kishino S, Itoh H.
-
Journal Title
Br J Clin Pharmacol
Volume: 80(6)
Issue: 6
Pages: 1421-1428
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Presentation] Phenoconversion of CYP3A in chronic renal failure; what is the factor involved?2017
Author(s)
Suzuki Y, Muraya N, Fujioka T, Sato F, Tanaka R, Matsumoto K, Sato Y, Ohno K, Mimata H, Kishino S, Itoh H
Organizer
15th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology
Place of Presentation
Kyoto International Conference Center, Kyoto, Japan
Year and Date
2017-09-24
Related Report
Int'l Joint Research
-
-
-
[Presentation] CYP3A5 polymorphism and accumulation of indoxyl sulfate affect the rate of increase in CYP3A activity after living kidney transplantation in patients with end stage renal disease.2015
Author(s)
Suzuki Y, Fujioka T, Muraya N, Sato F, Matsumoto K, Tanaka R, Sato Y, Ohno K, Mimata H, Kishino S, Itoh H.
Organizer
14th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology
Place of Presentation
Congress Centre De Doelen, Rotterdam, The Netherlands
Year and Date
2015-10-11
Related Report
Int'l Joint Research
-
[Presentation] CYP3A5 Polymorphism Affects the Increase in CYP3A Activity after Living Kidney Transplantation in Patients with End Stage Renal Disease.2015
Author(s)
Suzuki Y, Fujioka T, Sato F, Matsumoto K, Muraya N, Tanaka R, Sato Y, Ohno K, Mimata H, Kishino S, Itoh H.
Organizer
The 12th Congress of the European Association for Clinical Pharmacology and Therapeutics
Place of Presentation
Melia Castilla Hotel, Madrid, Spain
Year and Date
2015-06-27
Related Report
Int'l Joint Research