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Development of inhalable formulations of anti-fibrotic agents with reduced risk of side effects

Research Project

Project/Area Number 15K18928
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionUniversity of Shizuoka

Principal Investigator

Seto Yoshiki  静岡県立大学, 薬学部, 講師 (30744974)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords抗線維化薬 / 粉末吸入製剤 / 薬剤性光線過敏症 / 安全性 / Pirfenidone / 吸入粉末製剤
Outline of Final Research Achievements

This study aimed to develop respirable powder formulations of anti-fibrotic agents with minimal risk of side effects. Respirable powder formulations of anti-fibrotic agents, directly administered to the lungs, were prepared, and its physicochemical properties, efficacy, and safety were evaluated. Prepared respirable powder formulations had favorable inhalation properties. Insufflated formulations at low dose of drug indicated potent anti-inflammatory effects in experimental lung inflammatory model rats. The formulations at the pharmacologically effective dose after intratracheal administration also indicated lower systemic exposure, possibly leading to reducing the risk of side effects of anti-fibrotic agents. Inhalation thrapy using respirable powder formulation of anti-fibrotic agentsmay be a efficacious approach for the treatment of pulmonary fiblosis with wide safety margins.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (16 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (3 results) Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Acknowledgement Compliant: 3 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Int'l Joint Research] シドニー大学(オーストラリア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] シドニー大学(オーストラリア)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] シドニー大学(オーストラリア)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Enhanced pharmacokinetic behavior and hepatoprotective function of ginger extract-loaded supersaturable self-emulsifying drug delivery systems2018

    • Author(s)
      Ogino Mizuki、Yakushiji Keisuke、Suzuki Hiroki、Shiokawa Kenichi、Kikuchi Hiroshi、Seto Yoshiki、Sato Hideyuki、Onoue Satomi
    • Journal Title

      Journal of Functional Foods

      Volume: 40 Pages: 156-163

    • DOI

      10.1016/j.jff.2017.08.035

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enzymatic reactive oxygen species assay to evaluate phototoxic risk of metabolites2017

    • Author(s)
      Kato M, Ohtake H, Sato H, Seto Y, Onoue S
    • Journal Title

      Toxicol Lett

      Volume: 15 Pages: 59-65

    • DOI

      10.1016/j.toxlet.2017.07.852

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Avoidance of food effect on oral absorption profile of itraconazole by self-micellizing solid dispersion approach2017

    • Author(s)
      Kojo Y, Kobayashi K, Matsunaga S, Suzuki H, Seto Y, Sato H, Onoue S
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 32 Issue: 5 Pages: 273-276

    • DOI

      10.1016/j.dmpk.2017.06.001

    • NAID

      210000170142

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of sesamin-loaded solid dispersion with α-glycosylated stevia for improving physicochemical and nutraceutical properties2017

    • Author(s)
      Sato Hideyuki、Aoki Asako、Tabata Aiko、Kadota Kazunori、Tozuka Yuichi、Seto Yoshiki、Onoue Satomi
    • Journal Title

      Journal of Functional Foods

      Volume: 35 Pages: 325-331

    • DOI

      10.1016/j.jff.2017.05.054

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Amourphous solid dispersion of cyclosporine A prepared with fine droplet drying process: Physicochemical and pharmacokinetic characterization2017

    • Author(s)
      Hiroki Suzuki, Tatsuru Moritani, Tadahiko Morinaga, Yoshiki Seto, Hideyuki Sato, Satomi Onoue
    • Journal Title

      International Journal of Pharmaceutics

      Volume: 519 Issue: 1-2 Pages: 213-219

    • DOI

      10.1016/j.ijpharm.2017.01.018

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ginger extract-loaded solid dispersion system with enhanced oral absorption and anti-hypothermic action2017

    • Author(s)
      2)Hideyuki Sato, Mizuki Ogino, Keisuke Yakushiji, Hiroki Suzuki, Ken-ichi Shiokawa, Hiroshi Kikuchi, Yoshiki Seto, Satomi Onoue
    • Journal Title

      Journal of Agricultural and Food Chemistry

      Volume: 65 Issue: 7 Pages: 1365-1370

    • DOI

      10.1021/acs.jafc.6b04740

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Development of an improved inhalable powder formulation of pirfenidone by spray-drying: in vitro characterization and pharmacokinetic profiling2016

    • Author(s)
      2)Yoshiki Seto, Gen Suzuki, Sharon Shui Yee Leung, Hak-Kim Chan, Satomi Onoue
    • Journal Title

      Pharmaceutical Research

      Volume: 33(6) Issue: 6 Pages: 1447-1455

    • DOI

      10.1007/s11095-016-1887-3

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 吸入特性向上を指向した新規 pirfenidone 粉末吸入製剤の開発2017

    • Author(s)
      世戸 孝樹,鈴木 源,Sharon Leung,佐藤 秀行,Hak-Kim Chan,尾上 誠良
    • Organizer
      日本薬学会第 137 年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 世戸孝樹,鈴木源,佐藤秀行,尾上誠良2017

    • Author(s)
      副作用リスク低減ならびに肺局所作用持続を指向した新規 pirfenidone 徐放性粉末吸入製剤の開発
    • Organizer
      第 44 回 日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 安全性向上を指向した pirfenidone の DDS 研究2016

    • Author(s)
      世戸孝樹、佐藤秀行、尾上誠良
    • Organizer
      第 2 回 日本医薬品安全性学会学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2016-07-23
    • Related Report
      2016 Research-status Report
  • [Presentation] 体内動態制御により患者の QOL 改善に寄与する新規 pirfenidone 粉末吸入製剤の開発2016

    • Author(s)
      世戸孝樹,Hak-Kim Chan,尾上誠良
    • Organizer
      第 32 回 日本DDS学会学術集会
    • Place of Presentation
      静岡
    • Year and Date
      2016-06-30
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Developing a new respirable powder formulation of pirfenidone for reducing toxicity risk2015

    • Author(s)
      Yoshiki Seto, Asako Aoki, Gen Suzuki, Masashi Kato, Satomi Onoue
    • Organizer
      30th JSSX Annual Meeting
    • Place of Presentation
      Tokyo
    • Year and Date
      2015-11-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 粉末吸入製剤技術による pirfenidone の副作用リスク低減2015

    • Author(s)
      世戸孝樹,尾上誠良
    • Organizer
      第 18 回 間質性肺炎細胞分子病態研究会
    • Place of Presentation
      東京
    • Year and Date
      2015-08-22
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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