Role of galectin-1 as a target of suppression and prevention for metastasis of renal cell carcinoma

• Project/Area Number: 15K18944
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Mukogawa Women's University
• Principal Investigator: Yamamori Motohiro 武庫川女子大学, 薬学部, 講師 (10444613)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 臨床薬学 / galectin-1 / 腎臓がん / 遊走

Outline of Final Research Achievements

This study was performed to investigate the impact of galectin-1 in metastasis of renal cell carcinoma (RCC). Human RCC-derived ACHN cell line showed a significant increased migration after treatment with galectin-1, which may be mediated by regulation of the cytoskeletal dynamics. Meanwhile, we observed no effect of endogenous galectin-1 on RCC cell lines migration and invasion. This study suggests that galectin-1 can be considered as a target of suppression and prevention for metastasis of RCC.

Research Products

• [Journal Article] Pharmacokinetics of intravenous mycophenolate mofetil in allogeneic hematopoietic stem cell-transplanted Japanese patients (2018)
  • Author(s): Kurata Keiji、Yakushijin Kimikazu、Okamura Atsuo、Yamamori Motohiro、Ichikawa Hiroya、Sakai Rina、Mizutani Yu、Kakiuchi Seiji、Miyata Yoshiharu、Kitao Akihito、Kawamoto Shinichiro、Matsuoka Hiroshi、Murayama Tohru、Minami Hironobu
  • Journal Title: Cancer Chemotherapy and Pharmacology Volume: 81 Issue: 5 Pages: 839-846
  • DOI: 10.1007/s00280-018-3550-7
  • Peer Reviewed
• [Journal Article] In vitro and in vivo cytotoxicity of troglitazone in pancreatic cancer (2017)
  • Author(s): Fujita Megumi、Hasegawa Ai、Yamamori Motohiro、Okamura Noboru
  • Journal Title: Journal of Experimental & Clinical Cancer Research Volume: 36 Issue: 1 Pages: 91-91
  • DOI: 10.1186/s13046-017-0557-6
  • Peer Reviewed / Open Access
• [Presentation] Pharmacokinetics of intravenous mycophenolate mofetil after hematopoietic stem cell transplantation in Japanese population (2018)
  • Author(s): Kurata K, Okamura A, Yamamori M, Yakushijin K, Kawaguchi K, Higashime A, Ichikawa H, Sakai R, Mizutani Y, Kakiuchi S, Miyata Y, Kitao A, Kawamoto S, Matsuoka H, Minami H
  • Organizer: BMT Tandem Meetings
  • Int'l Joint Research
• [Presentation] 腎臓がん細胞の遊走に及ぼすgalectin-1の影響 (2016)
  • Author(s): 山森元博、川上恵、長谷川愛、山口京子、前沙織、大石真子、岡村昇
  • Organizer: 第26回日本医療薬学会年会
  • Place of Presentation: 京都
  • Year and Date: 2016-09-17