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Adverse effect of varenicline on cardiovascular disease under chronic obstructive pulmonary disease conditions

Research Project

Project/Area Number 15K18948
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionFukuoka University

Principal Investigator

Koga Mitsuhisa  福岡大学, 薬学部, 助教 (60570801)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords副作用 / 心血管 / 慢性閉塞性肺疾患 / バレニクリン / 心血管イベント
Outline of Final Research Achievements

Varenicline, a drug for smoking cessation, increases the risk of cardiovascular event. Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary inflammation and emphysema. In COPD patients, smoking cessation is one of the most effective treatments. However, it is unclear whether varenicline increases the risk of cardiovascular event under COPD conditions. In this study, to clarify the adverse effect of varenicline under COPD conditions, apolipoprotein E knockout (ApoE KO) mice were administrated porcine pancreatic elastase (PPE) to induce emphysema.
Varenicline promoted the atherosclerosis in ApoE KO mice, while it didn’t aggravate the atherosclerosis in PPE-treated ApoE KO mice. Interestingly, varenicline blocked the PPE-induced alveolar enlargement. In summary, varenicline may increase the risk of cardiovascular event and protect PPE-induced emphysema. Thus, the protective effect of varenicline against COPD may not promote the atherosclerosis under COPD conditions.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (5 results)

  • [Journal Article] Varenicline enhances oxidized LDL uptake by increasing expression of LOX-1 and CD36 scavenger receptors through α(7) nAChR in macrophages.2017

    • Author(s)
      Kanaoka Y, Koga M, Sugiyama K, Ohishi K, Kataoka Y, Yamauchi A.
    • Journal Title

      Toxicology

      Volume: 380 Pages: 62-71

    • DOI

      10.1016/j.tox.2017.02.006

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Elevated permeability of the blood-brain barrier in mice intratracheally2015

    • Author(s)
      Takata F, Tominaga K, Koga M, Dohgu S, Futagami K, Yamauchi A, Kataoka Y.
    • Journal Title

      J Pharmacol Sci.

      Volume: 129 Issue: 1 Pages: 78-81

    • DOI

      10.1016/j.jphs.2015.08.008

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Varenicline downregulates VE-cadherin expression and enhances HUVEC migration through α7 nAChR2017

    • Author(s)
      古賀允久、金岡祐輝、橋爪渚、田代哲士、片岡泰文、山内淳史
    • Organizer
      第90回 日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] Varenicline enhances oxLDL uptake into macrophages by increasing LOX-1 and CD36 scavenger receptor through α7 nAChR2017

    • Author(s)
      金岡祐輝、古賀允久、片岡泰文、山内淳史
    • Organizer
      第90回 日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] バレニクリンはマクロファージにおける酸化LDLによる泡沫化を促進する2016

    • Author(s)
      金岡祐輝、古賀允久、山内淳史、片岡泰文
    • Organizer
      第136回日本薬学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] バレニクリンはマクロファージにおけるoxLDLの取り込みを促進させる2015

    • Author(s)
      金岡祐輝、古賀允久、山内淳史、片岡泰文
    • Organizer
      第68回日本薬理学会西南部会
    • Place of Presentation
      下関
    • Year and Date
      2015-11-21
    • Related Report
      2015 Research-status Report
  • [Presentation] 血管内皮細胞における禁煙補助薬バレニクリンの遊走作用2015

    • Author(s)
      江島優佳、古賀允久、金岡祐輝、久永真未、田代哲士、橋爪渚、山内淳史、片岡泰文
    • Organizer
      第68回日本薬理学会西南部会
    • Place of Presentation
      下関
    • Year and Date
      2015-11-21
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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