| Project/Area Number |
15K18949
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyushu University of Health and Welfare |
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Principal Investigator |
Yoshida Hiroki 九州保健福祉大学, 薬学部, 講師 (90469411)
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| Research Collaborator |
KUROKAWA Masahiko 九州保健福祉大学, 薬学部, 教授 (80186527)
WATANABE Wataru 九州保健福祉大学, 薬学部, 教授 (50399218)
SUGITA Chihiro 九州保健福祉大学, 薬学部, 助教 (70632694)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 肥満 / 免疫細胞 / フラボノイド / ナリンゲニン / ヘスペリジン / 食品 / 予防医療 / セルフメディケーション / 糖尿病 |
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| Outline of Final Research Achievements |
We evaluated the preventive and improvement effects of familiar food factors against obesity-related diseases via regulating immune cells functions. Naringenin, a citrus flavonoid, suppressed the infiltration of macrophages, CD8 (+) T cells, B cells and neutrophils into adipose tissue in high-fat diet (HFD)-induced obese mice. Naringenin also suppressed MCP-1, MCP-3 and IL-6 expression in adipose tissue. These molecules are cytokines that influence immune cells functions. In addition, we made clear that hesperidin preparation, another citrus flavonoid, suppressed macrophages infiltration into adipose tissue in HFD-induced obese mice.
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