Analyses of mutual control mechanism between FMR1 and CPEB1.
| Project/Area Number |
15K18958
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Kansai Medical University |
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Principal Investigator |
OE Souichi 関西医科大学, 医学部, 助教 (70599331)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | FMR1 / CPEB1 / 脆弱X症候群 / 翻訳制御 / RNA安定性制御 |
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| Outline of Final Research Achievements |
The aim of this study is elucidation of the mutual translational control mechanism between FMR1, the causative gene of fragile X syndrome, and CPEB1 which acts as a translational repressor. We showed that CPEB co-localized with Fmr1 mRNA in the rat hippocampal neurons and interacted via CPE in the 3 'UTR. Furthermore, knockdown of CPEB1 increased the expression levels of FMR1 and the mitochondria-related genes.
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Report
(4 results)
Research Products
(8 results)
