• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Fate analysis of hippocampal neural stem cells from embryonic to adult stage

Research Project

Project/Area Number 15K18962
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General anatomy (including histology/embryology)
Research InstitutionTokyo Medical University

Principal Investigator

Kashiwagi Taichi  東京医科大学, 医学部, 助教 (10398232)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords海馬 / 歯状回 / 神経幹細胞 / 海馬歯状回
Outline of Final Research Achievements

In the hippocampus, neural stem cells (NSCs) are present even in adulthood, and neurogenesis occur throughout life. Therefore, the hippocampal NSCs presumably possess the special mechanisms to maintain stemness for long-term period. It is useful for regenerative therapies in the nervous system to find mechanisms of neurogenesis in adulthood. To accomplish this, it is necessary to uncover characteristics of adult hippocampal NSCs, however detail processes of adult hippocampal NSC generation and mechanisms of long-term maintenance has not been understood. In this study, we partly elucidated the mechanisms of adult hippocampal NSC generation.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2018 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (8 results)

  • [Journal Article] Dentate granule progenitor cell properties are rapidly altered soon after birth2017

    • Author(s)
      Matsue Kenta、Minakawa Shiori、Kashiwagi Taichi、Toda Keiko、Sato Toru、Shioda Seiji、Seki Tatsunori
    • Journal Title

      Brain Structure and Function

      Volume: 223 Issue: 1 Pages: 357-369

    • DOI

      10.1007/s00429-017-1499-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamics and function of CXCR4 in formation of the granule cell layer during hippocampal development2017

    • Author(s)
      Miura-Yamamoto Y, Shinohara H, Kashiwagi T, Sato T, Shioda S, Seki T
    • Journal Title

      Scientific Reports

      Volume: 7: 5647 Issue: 1 Pages: 1-14

    • DOI

      10.1038/s41598-017-05738-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] BMPシグナルによる海馬神経細胞形成制御2018

    • Author(s)
      柏木 太一、篠原 広志、塩田 清二、石 龍徳
    • Organizer
      第123回日本解剖学会総会・全国学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 胎生期海馬に存在する神経幹・前駆細胞の性質2017

    • Author(s)
      柏木太一、篠原広志、塩田清二、石龍徳
    • Organizer
      第122回日本解剖学会総会・全国学術集会
    • Place of Presentation
      長崎県長崎市 長崎大学坂本キャンパス
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] Control of granule and pyramidal cell generation by BMP signaling in the developing hippocampus2017

    • Author(s)
      Taichi Kashiwag, Seiji Shioda, Tatsunori Seki
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The role of BMP signaling regulation in the dentate gyrus formation2016

    • Author(s)
      Taichi Kashiwag, Seiji Shioda, Saki Ishihara, Tatsunori Seki
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      神奈川県横浜市 パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
  • [Presentation] Mechanisms of BMP signaling regulation in the developing hippocampus2016

    • Author(s)
      Taichi Kashiwag, Seiji Shioda, Saki Ishihara, Kenta Matsue, Tatsunori Seki
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      神奈川県横浜市 パシフィコ横浜
    • Year and Date
      2016-07-20
    • Related Report
      2015 Research-status Report
  • [Presentation] 胎生期海馬歯状回形成過程におけるBMPシグナルの役割2016

    • Author(s)
      柏木太一、塩田清二、石龍徳
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      福島県郡山市 ビックパレットふくしま
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] BMP signaling induce Gfap-expressing NSCs in the developing hippocampus2016

    • Author(s)
      柏木太一
    • Organizer
      東京医科歯科大学難治疾患研究所「難治疾患共同研究拠点」事業 第9回神経発⽣生討論会
    • Place of Presentation
      東京都文京区 東京医科歯科大学
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] BMP signaling induce Gfap-expressing NSCs which restrictedly exist in the developing hippocampus2015

    • Author(s)
      Taichi Kashiwag, Seiji Shioda, Tatsunori Seki
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      兵庫県神戸市 国際展示場
    • Year and Date
      2015-07-27
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi