| Project/Area Number |
15K18962
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 海馬 / 歯状回 / 神経幹細胞 / 海馬歯状回 |
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| Outline of Final Research Achievements |
In the hippocampus, neural stem cells (NSCs) are present even in adulthood, and neurogenesis occur throughout life. Therefore, the hippocampal NSCs presumably possess the special mechanisms to maintain stemness for long-term period. It is useful for regenerative therapies in the nervous system to find mechanisms of neurogenesis in adulthood. To accomplish this, it is necessary to uncover characteristics of adult hippocampal NSCs, however detail processes of adult hippocampal NSC generation and mechanisms of long-term maintenance has not been understood. In this study, we partly elucidated the mechanisms of adult hippocampal NSC generation.
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