Interaction between satellite cells and myofibroblasts: Activation control of satellite cells by HGF signaling

Research Project

Project/Area Number	15K18968
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	General physiology
Research Institution	Kobe University
Principal Investigator	HAYASHI Makoto 神戸大学, 医学研究科, 助教 (50722930)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	Ror1 / 衛星細胞 / 組織損傷修復 / 炎症性サイトカイン / 筋損傷修復
Outline of Final Research Achievements	Satellite cells, which are tissue stem cells of skeletal muscle, play crucial role in regeneration of skeletal muscle during injury. However, regulation mechanism of activation of satellite cells in injured muscles is not fully understood. We found that receptor tyrosine kinase Ror1 is selectively expressed in satellite cells, and its expression is enhanced during regeneration of injured muscles. Ror1 is transcriptionally regulated via NF-κB activated by IL-1β and TNF-α. Analysis of satellite cell-specific Ror1 knockout mice reveals that Ror1 is crucial for proliferation of satellite cells during regeneration of injured muscles.

Report

(3 results)