A study on the molecular mechanisms of epileptic phenotype in eEF1BdeltaL knockout mice
| Project/Area Number |
15K18971
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Kumamoto University |
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Principal Investigator |
KAITSUKA Taku 熊本大学, 大学院生命科学研究部(医), 助教 (00435926)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | てんかん / 恐怖条件付け / 熱ショックタンパク質 / ストレス / スプライシング |
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| Outline of Final Research Achievements |
In this study, we investigated the molecular mechanism of audiogenic seizure observed in eEF1BdeltaL knockout (KO) mouse. We found that epilepsy-related gene Cacna1a was significantly decreased in the brain of eEF1BdeltaL KO mice. Furthermore, induction of molecular chaperones was suppressed in the brain of these mice. After auditory stress, the brain atrophy was observed in KO mice. Molecular chaperones protect cells from various stresses. Our study suggests that eEF1BdeltaL might function as a safeguard against excessive response to environmental stress and gives new insight into molecular mechanism of stress-related psychiatric disorders.
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Report
(3 results)
Research Products
(9 results)
