Adipose insulin signaling regulated by brain KATP channel
Project/Area Number |
15K18977
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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Research Institution | National Center for Global Health and Medicine |
Principal Investigator |
OGURA KOHEI 国立研究開発法人国立国際医療研究センター, 研究所・感染症制御研究部, 上級研究員 (00586612)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | グルコース取り込み / インスリン応答 / KATPチャネル / Akt / 脂肪細胞 / インスリン / カリウムチャネル |
Outline of Final Research Achievements |
ATP-sensitive potassium (K(ATP)) channel is critical in metabolism control. Previous reports showed that insulin-dependent glucose uptake is enhanced in adipose tissues of KATP channel knockout (KO) mice compared with that in wild-type mice. Insulin stimulated in vivo interaction of Akt and unknown factor in adipose tissues. The interaction was enhanced dependent on amount of injected insulin. Akt2 mainly played role for the interaction in adipose tissues of KO mice. Mass spectrometry analysis showed 14-3-3 family proteins are candidates for the interaction with Akt2.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.2017
Author(s)
Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, Asara JM, Fukumoto S, Nakayama KI, Nakayama K, Inuzuka H, Wei W.
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Journal Title
Sci Signal. doi: 10.1126/scisignal.aah4117.
Volume: 10
Issue: 460
Pages: 1-15
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.2015
Author(s)
Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, Wang B, Blenis J, Cantley LC, Toker A, Su B, Wei W.
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Journal Title
Cancer Discovery
Volume: 5
Issue: 11
Pages: 1194-1209
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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