Analysis of the effect of gentle stroking stimuli on social behavior
| Project/Area Number |
15K18978
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Jichi Medical University |
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Principal Investigator |
Okabe Shota 自治医科大学, 医学部, 助教 (00747256)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 撫でる / 接触刺激 / 親和的関係 / オキシトシン / ラット / 超音波 |
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| Outline of Final Research Achievements |
Rats that had received gentle stroking stimuli emitted 50-kHz ultrasonic vocalizations, an index of positive emotion, during stroking stimuli. In addition, these rats showed higher preference for the stroking stimuli. These rats showed low level of anxiety-related behavior. Oxytocin neurons activated following stroking stimuli were mainly located in the caudal hypothalamic paraventricular nucleus (caudal PVN). Oxytocin neurons of the caudal PVN mainly project their axons toward several brain regions including cingulate cortex, insular cortex and hypothalamus area. In addition, stroking stimuli induced c-Fos protein, an index of neuronal activation, in the cingulate cortex and insular cortex. These findings suggest that post-weaning repeated stroking facilitates affiliative social response in rats possibly via activation of oxytocin neurons in the caudal PVN and cingulate cortex and insular cortex.
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| Academic Significance and Societal Importance of the Research Achievements |
撫で刺激を幼若期から繰り返し与えることで、ラットが成長後、撫で刺激を好むようになり、不安が低下したり、撫でてくれる人を嗜好したりするようになることがわかった。ホルモンの一種であるオキシトシンは生殖や社会行動に大きく影響を及ぼす因子であることが知られている。撫でられることを好むラットは、撫でられる時にオキシトシンを産生する特定の領域の神経細胞が活性化することが明らかになった。このことから、撫で刺激により快情動がもたらされ、不安が低下する現象の背景に特定の領域のオキシトシン産生細胞が関与する可能性が示された。撫で刺激がもたらす生物学的な機能とそのメカニズムを理解することに貢献した。
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Report
(5 results)
Research Products
(12 results)
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[Journal Article] Pup exposure facilitates retrieving behavior via the oxytocin neural system in female mice2017
Author(s)
Okabe, S., Tsuneoka, Y., Takahashi, A., Ooyama, R., Watarai, A., Maeda, S., Honda, Y., Nagasawa, M., Mogi, K., Nishimori, K., Kuroda, M., Koide, T., Kikusui, T.
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Journal Title
Psychoneuroendocrinology
Volume: 79
Pages: 20-30
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Structure and function of neonatal social communication in a genetic mouse model of autism.2016
Author(s)
T. Takahashi, S. Okabe, P. Ó Broin, A. Nishi, K. Ye, M. V. Beckert, T. Izumi, A. Machida, G. Kang, Seiji Abe, J. L. Pena, A. Golden, T. Kikusui, N. Hiroi.
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Journal Title
Molecular Psychiatry
Volume: in press
Issue: 9
Pages: 1-7
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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