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thermogenic pathways of progesterone and its metabolites in rats

Research Project

Project/Area Number 15K18979
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionNippon Medical School

Principal Investigator

Iwata Kinuyo  日本医科大学, 医学部, 講師 (00582991)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsプロゲステロン / 体温上昇 / 体温調節
Outline of Final Research Achievements

This study aims to determine thermogenic pathways of progesterone in female rats. Rectal temperatures were measured, but values were a lack of stability. Therefore, an implantable thermometer was utilized. To study whether progesterone induces thermogenesis, progesterone was subcutaneously injected or a progesterone-containing silicon tube was implanted in ovariectomized rats. Progesterone did not affect body temperatures. Our results did not coincide with previous studies. We will try other methods and study effects of its metabolite on thermogenesis.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2017 2016 2015 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 4 results) Presentation (1 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] Effect of Androgen on Kiss1 Expression and Luteinizing Hormone Release in Female Rats.2017

    • Author(s)
      Iwata K., Kunimura Y., Matsumoto K., Ozawa H
    • Journal Title

      Journal of Endocrinology

      Volume: April 4 Issue: 3 Pages: 1-13

    • DOI

      10.1530/joe-16-0568

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Age-related alterations in hypothalamic kisspeptin, neurokinin B, and dynorphin neurons and in pulsatile LH release in female and male rats2017

    • Author(s)
      Kunimura Y, Iwata K, Ishigami A, Ozawa H.
    • Journal Title

      Neurobiology of Aging

      Volume: 19 Pages: 30-38

    • DOI

      10.1016/j.neurobiolaging.2016.10.018

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Interactions between Kisspeptin Neurons and Hypothalamic Tuberoinfundibular Dopaminergic Neurons in Aged Female Rats2016

    • Author(s)
      Iwata K.,Ikehara M.,Kunimura Y.,Ozawa H
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 49 Issue: 6 Pages: 191-196

    • DOI

      10.1267/ahc.16027

    • NAID

      130006856397

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Immunoelectron microscopic observation of the subcellular localization of kisspeptin,neurokinin B and dynorphin A in KNDY neurons in the arcuate nucleus of the female rat2015

    • Author(s)
      Murakawa H.,Iwata K.,Takeshita T.,Ozawa H
    • Journal Title

      Neuroscience Letters

      Volume: 612 Pages: 161-166

    • DOI

      10.1016/j.neulet.2015.12.008

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Expression of androgen receptor in kisspeptin neurons of female rats2017

    • Author(s)
      Iwata K., Kunimura Y., Ozawa H.
    • Organizer
      9th international meeting STEROIDS AND NERVOUS SYSTEM
    • Place of Presentation
      Torino (Italy)
    • Year and Date
      2017-02-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 日本医科大学大学院 医学研究科 解剖学・神経生物学ホームページ

    • URL

      http://www2.nms.ac.jp/nms/kaibou2/publication.html

    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2018-03-22  

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