thermogenic pathways of progesterone and its metabolites in rats
Project/Area Number |
15K18979
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
|
Research Institution | Nippon Medical School |
Principal Investigator |
Iwata Kinuyo 日本医科大学, 医学部, 講師 (00582991)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | プロゲステロン / 体温上昇 / 体温調節 |
Outline of Final Research Achievements |
This study aims to determine thermogenic pathways of progesterone in female rats. Rectal temperatures were measured, but values were a lack of stability. Therefore, an implantable thermometer was utilized. To study whether progesterone induces thermogenesis, progesterone was subcutaneously injected or a progesterone-containing silicon tube was implanted in ovariectomized rats. Progesterone did not affect body temperatures. Our results did not coincide with previous studies. We will try other methods and study effects of its metabolite on thermogenesis.
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Report
(3 results)
Research Products
(6 results)