| Project/Area Number |
15K18981
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Waseda University |
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Principal Investigator |
Tahara Yu 早稲田大学, 高等研究所, 助教 (80707399)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 体内時計 / 腸内細菌 / 末梢臓器 / 概日時計 / 肝臓 / 短鎖脂肪酸 |
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| Outline of Final Research Achievements |
In this study, we demonstrated the effect of microbiota-derived short-chain fatty acid (SCFA) on the circadian clock system in mouse peripheral clocks. Cecal pH was lower and amount of cecal SCFA was higher in the beginning of dark period. Oral injection of SCFA in the daytime caused phase-advance of peripheral clocks. SCFA also caused phase entrainment of cellular clocks in fibroblasts with dose- and time-of-day dependency. In addition, fiber rich diet enhanced food-induced peripheral clock entrainment. Thus, our study revealed first application of chrono-nutrition using microbiota-derived SCFA.
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