| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The aim of this study was to examine an interactive role of neuropeptide Y (NPY) and brain histamine in the regulation of feeding rhythm. When mice were subjected to a scheduled feeding in which food availability is restricted for a few hours in a day, they develop food-anticipatory activity (FAA). Daily rhythm of FAA is controlled independent of light-evoked circadian cycle regulated by a mechanisms involving several clock genes but the mechanism underlying the daily food-anticipation remains elusive. The author demonstrated that mice lacking NPY-receptor (Y-R) manifest markedly reduced FAA. Correspondingly with the reduction of the FAA, activity of the histaminergic neurons in the tuberomammillary nucleus was significantly attenuated. In addition, both anti-histamine and histamine-release blocker reduced FAA. These evidence suggests that the histaminergic neurons were activated through Y-R to elicit FAA.
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