| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Outline of Final Research Achievements |
Macrophages (Mφs) are classified as M1 or M2 phenotypes, with the latter promoting angiogenesis which is a precipitating factor for several chronic inflammatory diseases including rheumatoid arthritis (RA) and various cancers. In this study, we initially established the simplified in vitro experimental model to evaluate the influence of micromilieu on the Mφ polarization status, morphology, and functional activity. As a result, M2-like Mφ strongly induced excessive angiogenesis through the direct cell-cell interaction with endothelial cells mediated by the surface CD163.
|
