Research Project
Grant-in-Aid for Young Scientists (B)
Hematopoietic stem cells and multipotent progenitors (MPPs) commitment can be tuned in response to an infection so that their differentiation is biased toward myeloid cells. Here we find that Bach2, which inhibits myeloid differentiation in common lymphoid progenitors, represses a cohort of myeloid genes and activates those linked to lymphoid function. Bach2 repressed both Cebpb and its target Csf1r, encoding C/EBPβ and macrophage colony-stimulating factor receptor (M-CSFr), respectively, whereas C/EBPβ repressed Bach2 and activated Csf1r. Bach2 and C/EBPβ further bound to overlapping regulatory regions at their myeloid target genes.Lipopolysaccharide reduced the expression of Bach2, resulting in enhanced myeloid differentiation. The Bach2-C/EBPβ GRN pathway thus tunes MPP commitment to myeloid and lymphoid lineages under both normal conditions and after infection.
All 2017 2016 2015
All Journal Article (2 results) (of which Peer Reviewed: 2 results, Open Access: 2 results, Acknowledgement Compliant: 2 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)
Cell Reports
Volume: 18 Issue: 10 Pages: 2401-2414
10.1016/j.celrep.2017.02.029
Current Opinion Immunology
Volume: 39 Pages: 136-142
10.1016/j.coi.2016.01.012
