| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
This study object is to determine target molecules of autophagy related small chemical compounds, such as chloroquine and metformin, and to elucidate the relationships between functions of the molecules and effects of the compounds. TOF-MS analysis revealed the metformin binding protein (MBP) was HMGB1. Metformin inhibited proinflammatory effect of HMGB1 in vitro and in vivo. Furthermore, metformin ameliorated liver injury induced by acetaminophen, as same as anti-HMGB1 antibody. This study elucidated one of an anti-inflammatory target molecule of metformin.
|
