Mechanism of Axl and Mer dependent efferocytosis of microglia

Research Project

Project/Area Number	15K19009
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	General medical chemistry
Research Institution	Osaka University
Principal Investigator	Yanagihashi Yuichi 大阪大学, 免疫学フロンティア研究センター, 特任研究員(常勤) (50611886)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	Axl / Mer / 死細胞貪食 / TAMレセプター / ミクログリア / 貪食
Outline of Final Research Achievements	Analysis of Mer defficient mouse revealed that microglia engulfed apoptotic cells through Axl and Mer receptor tyrosine kinase. But, their ability to enhancement efferocytosis and requirement of their ligand - Protein S and Gas6 were not quantitatively determined. In this study, microglial efferocytosis was characterized by quantitative analysis of the ability to enhancement of efferocytosis and comparison between microglia and various macrophages.

Report

(3 results)