Molecular mechanisms for plasma membrane damage-dependent cellular senescence
| Project/Area Number |
15K19012
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Nagoya City University |
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Principal Investigator |
KONO Keiko 名古屋市立大学, 大学院医学研究科, 講師 (30632723)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 細胞創傷治癒 / 細胞老化 / 老化 / 出芽酵母 / ストレス / 脂質 |
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| Outline of Final Research Achievements |
We found that physical damage to the plasma membrane induces the formation of "scars", membrane projections with altered lipid composition, after plasma membrane repair in budding yeast and human cultured cells. Genetic manipulation that removes the scars significantly extended yeast replicative lifespan. These results suggest that the scar itself, or the altered phospholipid composition, seems to be a cause for cellular senescence after plasma membrane damage. During the course of these studies, we unexpectedly discovered a previously unappreciated cell cycle checkpoint that senses plasma membrane damage. The "plasma membrane damage checkpoint" transiently arrests the cell cycle in yeasts and human cultured cells.
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Report
(3 results)
Research Products
(16 results)
