The functional analysis of cancer development and progression

• Project/Area Number: 15K19017
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry
• Research Institution: Nihon University
• Principal Investigator: TANIGUCHI Hiroaki 日本大学, 医学部, 研究員 (50587441)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: がんゲノム / 転写因子 / ガンゲノム / ゲノムシークセンス / がん

Outline of Final Research Achievements

Since the HNF4A knockout mouse exhibits tumor development in the liver, it has been suggested that HNF4A loss-of-function mutations triggerliver cancer development and its progression. However, comprehensive functional analysis for the mutations in human liver cancer have not been performed. This study allows us to investigate for the first time the importance of HNF4 mutations in liver cancer.Our study has revealed that HNF4 mutations would casue crucial mutations by loss or reduce of the function of HNF4A.