| Project/Area Number |
15K19030
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 炎症性反応 / 分化 / マクロファージ / Taxilin / 炎症性メディエーター / 細胞分化 |
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| Outline of Final Research Achievements |
Taxilin family members were identified as binding partners of the syntaxin family, known to play a central role in intracellular vesicle trafficking. Alpha- and gamma-taxilins favorably bind to syntaxin-4, known to be involved in inflammatory mediator release. Recent reports demonstrate that taxilin may be involved in function of inflammatory cells. Then, we examined whether taxilin is involved in release of inflammatory mediators. The amounts of both alpha- and gamma-taxilin proteins were decreased during differentiation of monocyte into macrophage and the decrease in protein levels of these proteins was regulated at transcriptional level. Neither of alpha- or gamma-taxilin depletion caused any change in the processes of differentiation of monocyte into macrophage. However, gamma-taxilin depletion attenuated lipopolysaccharide-induced production of inflammatory mediators in macrophage. These results suggest that taxilin might be involved in production of inflammatory mediators.
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