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The role of ST2, a receptor for cytokine IL-33, in the pathogenesis of cancer/autoimmune disease

Research Project

Project/Area Number 15K19031
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionTokyo University of Science

Principal Investigator

KAMACHI Fumitaka  東京理科大学, 理工学部応用生物科学科, 助教 (00747800)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsST2
Outline of Final Research Achievements

The pathogenesis of multiple sclerosis, an autoimmune disease affecting the brain and spinal cord, remains poorly understood. Although obesity is known to be a risk factor for several types of cancer including hepatocellular carcinoma, the exact mechanisms have remained largely unclear. In this study, we tried to investigate whether ST2, a receptor for cytokine interleukin-33, could be a therapeutic target for multiple sclerosis and obesity-associated hepatocellular carcinoma. We found that the inhibition of ST2 signaling attenuated the symptoms of multiple sclerosis model mice and the development of obesity-associated hepatocellular carcinoma in mice.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (30 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 4 results) Presentation (19 results) (of which Int'l Joint Research: 6 results,  Invited: 2 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] ITRBM(Taiwan)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Memorial Sloan Kettering Cancer Center(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Breastfeeding regulates development of immune system through TGF-β in mice pups2018

    • Author(s)
      Sakaguchi Keita、Koyanagi Akemi、Kamachi Fumitaka、Harauma Akiko、Chiba Asako、Hisata Ken、Moriguchi Toru、Shimizu Toshiaki、Miyake Sachiko
    • Journal Title

      Pediatr Int

      Volume: 60(3) Issue: 3 Pages: 224-231

    • DOI

      10.1111/ped.13507

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells2018

    • Author(s)
      Takahashi A, Loo TM, Okada R, Kamachi F, Watanabe Y, Wakita M, Watanabe S, Kawamoto S, Miyata K, Barber GN, Ohtani N, Hara E
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 1249-1249

    • DOI

      10.1038/s41467-018-03555-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gut microbiota promotes obesity-associated liver cancer through PGE2-mediated suppression of antitumor immunity.2017

    • Author(s)
      Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo M, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N.
    • Journal Title

      Cancer Discov

      Volume: in press Issue: 5 Pages: 522-538

    • DOI

      10.1158/2159-8290.cd-16-0932

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characteristics of alveolar macrophages from murine models of OVA-induced allergic airway inflammation and LPS-induced acute airway inflammation2015

    • Author(s)
      1)Katsura Y, Harada N, Harada S, Ishimori A, Makino F, Ito J, Kamachi F, Okumura K, Akiba H, Atsuta R, Takahashi K
    • Journal Title

      Experimental Lung Research

      Volume: 41 Issue: 7 Pages: 370-382

    • DOI

      10.3109/01902148.2015.1044137

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] ICOS promotes group 2 innate lymphoid cell activation in lungs2015

    • Author(s)
      Kamachi F, Isshiki T, Harada N, Akiba H, Miyake S
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 463 Issue: 4 Pages: 739-745

    • DOI

      10.1016/j.bbrc.2015.06.005

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] IL-33/ST2 pathway promotes obesity-associated liver cancer development2017

    • Author(s)
      Fumitaka Kamachi, Masaru Nakamura, Shota Yamazaki, Tze Mun Loo, Shin Yoshimoto, Tatsuya Arai, Yohsuke Harada, Masato Kubo, Susumu Nakae, Eiji Hara, Naoko Ohtani
    • Organizer
      The 19h Takeda Science Foundation Symposium on Biosciences
    • Place of Presentation
      武田薬品研修所(大阪府・吹田市)
    • Year and Date
      2017-01-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Synergism of SASP factors: activation mechanism of interleukin-33 in senescent hepatic stellate cells in promoting obesity-associated liver cancer2017

    • Author(s)
      Shota Yamazaki, Fumitaka Kamachi, Masaru Nakamura, Masahiro Nakajima, Tze Mun Loo, Shin Yoshimoto, Tatsuya Arai, Hayao Taguchi, Susumu Nakae, Eiji Hara, Naoko Ohtani
    • Organizer
      The 19h Takeda Science Foundation Symposium on Biosciences
    • Place of Presentation
      武田薬品研修所(大阪府・吹田市)
    • Year and Date
      2017-01-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] The gut microbiota-mediated TLR2-COX2 axis promotes obesity-associated liver cancer through evasion of anti-tumor immunity by PGE22017

    • Author(s)
      Yoshihiro Watanabe, Tze Mun Loo, Fumitaka Kamachi, Shin Yoshimoto, Yuriko Arai, Masaru Nakamura, Miho Kumagai, Masanobu Oshima, Eiji Hara, Naoko Ohtani
    • Organizer
      The 19h Takeda Science Foundation Symposium on Biosciences
    • Place of Presentation
      武田薬品研修所(大阪府・吹田市)
    • Year and Date
      2017-01-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 腸内細菌代謝産物が形成する肝癌微小環境におけるinterleukin-33の役割解明2017

    • Author(s)
      蒲池 史卓、中村 大、山﨑 翔太、中島 将博、羅 智文、吉本 真、新井 達也、原田 陽介、久保 允人、田口 速男、中江 進、原 英二、大谷 直子
    • Organizer
      第1回消化器臓器間ネットワーク研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Gut microbiota promotes obesity-associated liver cancer through PGE2-mediated suppression of antitumor immunity2017

    • Author(s)
      Tze Mun Loo, Fumitaka Kamachi, Yoshihiro Watanabe, Yuriko Arai, Hiroaki Kanda, Eiji Hara and Naoko Ohtani
    • Organizer
      Keystone symposia Aging and Mechanisms of Aging-Related Disease
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IL-33 from senescent hepatic stellate cells promotes obesity-associated liver cancer development by suppressing antitumor immunity2017

    • Author(s)
      Kamachi F, Nakamura M, Yamazaki S, Nakae S, Hara E, Ohtani N
    • Organizer
      19th International Symposium on Cells of the Hepatic Sinusoid
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Obesity-associated gut microbiota and cancer development2017

    • Author(s)
      Ohtani N, Loo TM, Kamachi F
    • Organizer
      第76回日本癌学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] A novel SASP factor IL-33 promotes obesity-associated liver cancer development2017

    • Author(s)
      Fumitaka Kamachi
    • Organizer
      International Symposium of the Center for Animal Disease Models 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 腸内細菌叢が肥満誘導性肝癌の進展を促進する:デオキシコール酸(DCA)とリポタイコ酸(LTA)の協調作用2017

    • Author(s)
      羅 智文、蒲池 史卓、渡辺 喜洋、神田  浩明、大島  正伸、岩間  厚志、有田 誠、原 英二、大谷 直子
    • Organizer
      ConBio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肝臓オルガノイドを用いた肥満誘導性肝臓がん発症モデルの構築及び、がんの起源細胞の解明2017

    • Author(s)
      窪田 達寛、安藤 達也、福井 優也、渡辺 喜洋、小澤 崇之、蒲池 史卓、八尾 良司、佐藤 俊朗、大谷 直子
    • Organizer
      ConBio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] SASP因子の相乗効果による肥満誘導性肝がん形成促進機構の解明2017

    • Author(s)
      山崎 翔太、蒲池 史卓、中村 大、中島 将博、Loo Mun、吉本 真、新井 達也、田口 速男、中江 進、原 英二、大谷 直子
    • Organizer
      ConBio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 腸内細菌によるリノール酸代謝産物の免疫系への作用2017

    • Author(s)
      新井 達也、蒲池 史卓、有田 誠、岸野 重信、小川 順、大谷 直子
    • Organizer
      ConBio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effects of gut microbial metabolites of linoleic acid on cytokine production by immune cells2017

    • Author(s)
      Fumitaka Kamachi, Tatsuya Arai, Makoto, Arita, Naoko Ohtani
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] IL-33 promotes obesity-associated liver cancer development2016

    • Author(s)
      Fumitaka Kamachi, Shota Yamazaki, Tatsuya Arai, Yohsuke Harada, Masato Kubo, Susumu Nakae, and Naoko Ohtani
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県・宜野湾市)
    • Year and Date
      2016-12-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 肥満誘導性肝臓癌におけるinterleukin-33の役割解明2016

    • Author(s)
      中村 大、蒲池 史卓、山崎 翔太、新井 達也、原田 陽介、久保 允人、羅 智文、吉本 真、中江 進、原 英二、大谷 直子
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-12-02
    • Related Report
      2016 Research-status Report
  • [Presentation] 規則的な運動は肥満誘導性肝腫瘍の発症を抑制する2016

    • Author(s)
      熊谷 実保、蒲池 史卓、安藤 達也、新井 友里子、井手口 真理、中村 大、小澤 崇之、渡辺 喜洋、山埼 翔太、羅 智文、大谷 直子
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-12-02
    • Related Report
      2016 Research-status Report
  • [Presentation] 肥満誘導性の腸内細菌代謝物による肝星細胞の細胞老化・SASPと肝がんの促進2016

    • Author(s)
      羅 智文、蒲池 史卓、渡辺 喜洋、大谷 直子
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-12-02
    • Related Report
      2016 Research-status Report
  • [Presentation] ICOS promotes group 2 innate lymphoid cell activation in lungs2015

    • Author(s)
      Fumitaka Kamachi, Takuma Isshiki, Norihiro Harada, Hisaya Akiba, Sachiko Miyake
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] グループ2自然リンパ球活性化におけるICOSの役割の検討2015

    • Author(s)
      蒲池 史卓、一色 琢磨、原田 紀宏、秋葉 久弥、三宅 幸子
    • Organizer
      第8回 Symphony
    • Place of Presentation
      ホテルメトロポリタンエドモント飯田橋(東京都千代田区)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report
  • [Remarks] 東京理科大学理工学部応用生物科学科

    • URL

      http://www.rs.tus.ac.jp/ohtani-lab/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 東京理科大学理工学部応用生物科学科大谷研究室ホームページ

    • URL

      http://www.rs.tus.ac.jp/ohtani-lab/

    • Related Report
      2016 Research-status Report 2015 Research-status Report
  • [Remarks] 順天堂大学医学部免疫学講座ホームページ

    • URL

      http://www.juntendo.ac.jp/graduate/laboratory/labo/meneki/home.html

    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] Use of EP4 receptor antagonists for the treatment of NASH-associated liver cancer2016

    • Inventor(s)
      大谷直子、蒲池史卓、他3名
    • Industrial Property Rights Holder
      大谷直子、蒲池史卓、他3名
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-11-04
    • Related Report
      2016 Research-status Report
    • Overseas

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Published: 2015-04-16   Modified: 2022-08-18  

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