The role of ST2, a receptor for cytokine IL-33, in the pathogenesis of cancer/autoimmune disease
Project/Area Number |
15K19031
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pathological medical chemistry
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Research Institution | Tokyo University of Science |
Principal Investigator |
KAMACHI Fumitaka 東京理科大学, 理工学部応用生物科学科, 助教 (00747800)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | ST2 |
Outline of Final Research Achievements |
The pathogenesis of multiple sclerosis, an autoimmune disease affecting the brain and spinal cord, remains poorly understood. Although obesity is known to be a risk factor for several types of cancer including hepatocellular carcinoma, the exact mechanisms have remained largely unclear. In this study, we tried to investigate whether ST2, a receptor for cytokine interleukin-33, could be a therapeutic target for multiple sclerosis and obesity-associated hepatocellular carcinoma. We found that the inhibition of ST2 signaling attenuated the symptoms of multiple sclerosis model mice and the development of obesity-associated hepatocellular carcinoma in mice.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells2018
Author(s)
Takahashi A, Loo TM, Okada R, Kamachi F, Watanabe Y, Wakita M, Watanabe S, Kawamoto S, Miyata K, Barber GN, Ohtani N, Hara E
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Journal Title
Nature Communications
Volume: 9
Issue: 1
Pages: 1249-1249
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Gut microbiota promotes obesity-associated liver cancer through PGE2-mediated suppression of antitumor immunity.2017
Author(s)
Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo M, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N.
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Journal Title
Cancer Discov
Volume: in press
Issue: 5
Pages: 522-538
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Characteristics of alveolar macrophages from murine models of OVA-induced allergic airway inflammation and LPS-induced acute airway inflammation2015
Author(s)
1)Katsura Y, Harada N, Harada S, Ishimori A, Makino F, Ito J, Kamachi F, Okumura K, Akiba H, Atsuta R, Takahashi K
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Journal Title
Experimental Lung Research
Volume: 41
Issue: 7
Pages: 370-382
DOI
Related Report
Peer Reviewed
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[Presentation] IL-33/ST2 pathway promotes obesity-associated liver cancer development2017
Author(s)
Fumitaka Kamachi, Masaru Nakamura, Shota Yamazaki, Tze Mun Loo, Shin Yoshimoto, Tatsuya Arai, Yohsuke Harada, Masato Kubo, Susumu Nakae, Eiji Hara, Naoko Ohtani
Organizer
The 19h Takeda Science Foundation Symposium on Biosciences
Place of Presentation
武田薬品研修所(大阪府・吹田市)
Year and Date
2017-01-20
Related Report
Int'l Joint Research
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[Presentation] Synergism of SASP factors: activation mechanism of interleukin-33 in senescent hepatic stellate cells in promoting obesity-associated liver cancer2017
Author(s)
Shota Yamazaki, Fumitaka Kamachi, Masaru Nakamura, Masahiro Nakajima, Tze Mun Loo, Shin Yoshimoto, Tatsuya Arai, Hayao Taguchi, Susumu Nakae, Eiji Hara, Naoko Ohtani
Organizer
The 19h Takeda Science Foundation Symposium on Biosciences
Place of Presentation
武田薬品研修所(大阪府・吹田市)
Year and Date
2017-01-20
Related Report
Int'l Joint Research
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