| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The pathogenesis of multiple sclerosis, an autoimmune disease affecting the brain and spinal cord, remains poorly understood. Although obesity is known to be a risk factor for several types of cancer including hepatocellular carcinoma, the exact mechanisms have remained largely unclear. In this study, we tried to investigate whether ST2, a receptor for cytokine interleukin-33, could be a therapeutic target for multiple sclerosis and obesity-associated hepatocellular carcinoma. We found that the inhibition of ST2 signaling attenuated the symptoms of multiple sclerosis model mice and the development of obesity-associated hepatocellular carcinoma in mice.
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