| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Tuberculosis (TB) is known to be affected by host genetic factors. A young age onset specific genetic risk of MAFB-related SNP was reported in the Thai population. In this study, I further focused on the heterogeneity of Mycobacterium tuberculosis (MTB) lineages and assessed its possible interaction with age at onset and host genetic factors. I found non-Beijing lineage dependent risk of MAFB-related SNP. In addition, GWAS stratified by both infected pathogen lineage information and age at onset revealed a genome-wide significant association of one SNP at CD53 locus. The results were reported on Journal of Human Genetics and it is the first report of GWAS considering the pathogen genomic information in TB. This research project proposed that host genetic risk for TB onset is depended upon the pathogen genetic background and demonstrated the importance of analyzing the interaction between host and pathogen genomes in TB.
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