Integrative analysis of human and Mycobacterium tuberculosis genomic variations to identify genetic risk factors for tuberculosis onset
Project/Area Number |
15K19039
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Human genetics
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Research Institution | The University of Tokyo |
Principal Investigator |
Omae Yosuke 東京大学, 大学院医学系研究科(医学部), 特任助教 (70722552)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 結核 / ヒトゲノム / 病原菌ゲノム / 感染症 / ゲノムワイド関連解析 / 結核症 / 菌体ゲノム / 宿主ゲノム / タイ王国 |
Outline of Final Research Achievements |
Tuberculosis (TB) is known to be affected by host genetic factors. A young age onset specific genetic risk of MAFB-related SNP was reported in the Thai population. In this study, I further focused on the heterogeneity of Mycobacterium tuberculosis (MTB) lineages and assessed its possible interaction with age at onset and host genetic factors. I found non-Beijing lineage dependent risk of MAFB-related SNP. In addition, GWAS stratified by both infected pathogen lineage information and age at onset revealed a genome-wide significant association of one SNP at CD53 locus. The results were reported on Journal of Human Genetics and it is the first report of GWAS considering the pathogen genomic information in TB. This research project proposed that host genetic risk for TB onset is depended upon the pathogen genetic background and demonstrated the importance of analyzing the interaction between host and pathogen genomes in TB.
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Report
(4 results)
Research Products
(13 results)
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[Presentation] Pathogen lineage based genome-wide analysis of host genetic risk factors in tuberculosis2016
Author(s)
大前陽輔, Surakameth Mahasirimongkol, 豊岡理人, 野内英樹, Supalert Nedsuwan, Sukanya Wattanapokayakit, Nat Smittipat, Prasit Paliittapongarnpim, Pathom Sawanpanyalert, Nuanjun Wichukchinda, Ekawat Pasomsub, 莚田泰誠, 久保充明, 徳永勝士
Organizer
第16回生命科学シンポジウム
Place of Presentation
21KOMCEE(東京都目黒区)
Year and Date
2016-04-23
Related Report
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[Presentation] Pathogen lineage based analysis of host genetic risk factor in young onset tuberculosis2016
Author(s)
Yosuke Omae, Surakameth Mahasirimongkol, Licht Toyo-oka, Hideki Yanai, Supalert Nedsuwan, Sukanya Wattanapokayakit, Nat Smittipat, Prasit Palittapongarnpim, Pathom Sawanpanyalert, Nuanjun Wichukchinda, Ekawat Pasomsub, Taisei Mushiroda, Michiaki Kubo, and Katsushi Tokunaga
Organizer
The 13th International Congress of Human Genetics (ICHG)’(国際人類遺伝学会)
Place of Presentation
国立京都国際会館(京都府京都市)
Year and Date
2016-04-03
Related Report
Int'l Joint Research
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[Presentation] Pathogen lineage based analysis of host genetic risk factor in young onset tuberculosis2016
Author(s)
Yosuke Omae, Surakameth Mahasirimongkol, Licht Toyo-oka, Hideki Yanai, Supalert Nedsuwan, Sukanya Wattanapokayakit, Nat Smittipat, Prasit Paliittapongarnpim, Pathom Sawanpanyalert, Nuanjun Wichukchinda, Ekawat Pasomsub, Taisei Mushiroda, Michiaki Kubo, and Katsushi Tokunaga.
Organizer
The 13th International Congress of Human Genetics (ICHG)
Place of Presentation
国立京都国際会館(京都府京都市)
Year and Date
2016-04-03
Related Report
Int'l Joint Research
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