Epigenetic regulation of inflammatory genes associated with the rupture of intracranial aneurysms

Research Project

Project/Area Number	15K19043
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Human genetics
Research Institution	National Institute of Genetics
Principal Investigator	Nakaoka Hirofumi 国立遺伝学研究所, 総合遺伝研究系, 助教 (70611193)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords	脳動脈瘤 / くも膜下出血 / マクロファージ / 炎症反応 / エピジェネティクス
Outline of Final Research Achievements	In our previous study, we demonstrated that macrophage-mediated inflammation is a key biological pathway for the rupture of intracranial aneurysms. We focused on the inflammatory transcription factors associated with the rupture of intracranial aneurysms. We explored the expression profiles of genes with binding motifs of these transcription factors, and constructed a hierarchical transcriptional regulatory networks associated with the rupture of intracranial aneurysms. We performed epigenetic analysis of these genes.

Report

(3 results)