Epigenetic regulation of inflammatory genes associated with the rupture of intracranial aneurysms

• Project/Area Number: 15K19043
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human genetics
• Research Institution: National Institute of Genetics
• Principal Investigator: Nakaoka Hirofumi 国立遺伝学研究所, 総合遺伝研究系, 助教 (70611193)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 脳動脈瘤 / くも膜下出血 / マクロファージ / 炎症反応 / エピジェネティクス

Outline of Final Research Achievements

In our previous study, we demonstrated that macrophage-mediated inflammation is a key biological pathway for the rupture of intracranial aneurysms. We focused on the inflammatory transcription factors associated with the rupture of intracranial aneurysms. We explored the expression profiles of genes with binding motifs of these transcription factors, and constructed a hierarchical transcriptional regulatory networks associated with the rupture of intracranial aneurysms. We performed epigenetic analysis of these genes.

Research Products

• [Journal Article] Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms. (2016)
  • Author(s): van 't Hof FN, Ruigrok YM, Lee CH, Ripke S, Anderson G, Wang GT; Aneurysm Consortium; Vascular Research Consortium of New Zealand, Han B, Rinkel GJ, de Bakker PI et al.
  • Journal Title: J Am Heart Assoc Volume: 5 Issue: 7
  • DOI: 10.1161/jaha.115.002603
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Shared genetic risk factors of intracranial, abdominal and thoracic aneurysms (2016)
  • Author(s): van’t Hof FNG, et al.
  • Journal Title: J Am Heart Assoc Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research