Local estrogen synthesis in brain metastasis of breast cancer
| Project/Area Number |
15K19044
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 乳癌 / 病理学 / 遠隔転移 / 脳転移 / エストロゲン / 転移 / 間質細胞 / アストロサイト / 癌間質 |
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| Outline of Final Research Achievements |
We collected metastatic tumor tissues from breast cancer patients. Metastatic sites included brain, lung and bone. Histopathological and immunohistochemical analysis of metastatic tumors was done. We reported these results at the 104 th Annual Meeting of the Japanese Society of Pathology. Next, we did in vitro studies using rat and human astrocytes and breast cancer cells. Astrocytes and cancer cells were cocultured and analyzed for proliferation. RNA and cytokines were measured using microRNA microarray and cytokine array. Further analysis is ongoing.
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Report
(3 results)
Research Products
(1 results)
