Clinicopathological analysis of mature T/NK-cell lymphoma
| Project/Area Number |
15K19052
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Nagoya University |
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Principal Investigator |
Kato Seiichi 名古屋大学, 医学系研究科, 准教授 (30584669)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 成熟T/NK細胞リンパ腫 / 鼻型NK/T細胞リンパ腫 / EBV / 細胞傷害性分子 / 節外性NK/T細胞リンパ腫，鼻型 / 皮膚原発 |
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| Outline of Final Research Achievements |
Extranasal NK/T-cell lymphoma of nasal type (ENKTL) is characterized by an aggressive clinical course, and its prevalence is relatively high in Asia. In our studies, we demonstrated that primary cutaneous ENKTL was characterized by an older onset age, more favorable clinical course and a female predominance. In addition, we showed significant heterogeneity of EBV+ intestinal EBV+ T/NK-cell lymphoma and its relationship with chronic active EBV infection, especially in patients younger than 50 years of age. Among EBV+ intestinal EBV+ T/NK-cell lymphoma cases, CD56-positive patients had a poorer prognosis than those without CD56 expression.
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Report
(3 results)
Research Products
(2 results)
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[Journal Article] Clinicopathological analysis of 12 patients with Epstein-Barr virus-positive primary intestinal T/natural killer-cell lymphoma (EBV+ ITNKL).2017
Author(s)
Hu LM, Takata K, Miyata-Takata T, Asano N, Takahashi E, Furukawa K, Miyoshi H, Satou A, Kohno K, Kosugi H, Kinoshita T, Hirooka Y, Goto H, Nakamura S, Kato S.
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Journal Title
Histopathology
Volume: 印刷中
Issue: 7
Pages: 1052-1063
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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