| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In this study, we investigated hypotheses that the formation of intracellular organelle called endocrine granule is controlled by PROX1 gene. Most cells and tissues having endocrine granules expressed high levels of PROX1. Suppression of PROX1 expression in cell lines with endocrine granules reduced the number of endocrine granules, as well as the expression of several genes constituting endocrine granule. Conversely, the PROX1 gene is introduced into a cell line not having endocrine granules, the expression of endocrine granule constituent gene group is enhanced; it was thought that which is caused by directly acting of PROX1 on the transcription regulatory region of the genes. This study revealed for the first time endocrine cell-specific transcriptional regulator that positively control the formation of endocrine granules.
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