| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
First, NGS data analysis showed that all the studied SSA/Ps with dysplasia/carcinoma harbored no GNAS mutation, suggesting that serrated neoplasia pathway might not be associated with G-protein-coupled receptor protein signaling pathway.Second, our endoscopic studies indicated that endoscopic characteristics, including (semi)pedunculated morphology, double elevation, central depression, and reddishness, in addition to the use of magnifying endoscopy, might be useful to accurately diagnose advanced histology within an SSA/P. Third, histopathologically, carcinomas arising in SSA/P exhibited a higher potential for lymphatic invasion and lymph node metastasis and have distinct histopathological features, including mucinous component, serrated architecture, tumour-infiltrating lymphocytes,Crohn-like inflammatory reaction, and absence of desmoplastic reaction, compared to counterparts arising in conventional adenoma.
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