| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Gastric adenocarcinoma of fundic gland type (GAFG) is classified into pure GAFG and gastric adenocarcinoma of fundic gland mucosal type (GAFGM) which exhibited differentiation toward gastric foveolar epithelium in addition to fundic gland differentiation, histopathologically. This histopathological classification of GAFG is useful to estimate its malignant potential. The comprehensive genetic analysis using next generation sequencing of GAFG identified that GAFG is a neoplasm with low-grade malignancy, and the frequent presence of GNAS mutation is a characteristic genetic feature of GAFG, both pure GAFG and GAFGM (GAFG: 21.4%, pure GAFG: 19.0%, GAFGM: 28.6%). We will verify the specificity of obtained oncogenic driver mutations and speculate the signaling pathway of carcinogenesis of GAFG.
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