Carcinogenesis mechanism of gastric adenocarcinoma of fundic gland type
Project/Area Number |
15K19060
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Human pathology
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Research Institution | Juntendo University |
Principal Investigator |
UEYAMA Hiroya 順天堂大学, 医学部, 准教授 (60621935)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 胃癌 / 胃底腺型胃癌 / 次世代シークエンス / GNAS mutation / 胃底腺粘膜型胃癌 / 次世代シーケンサ / pepsinogen-I / 胃底腺 |
Outline of Final Research Achievements |
Gastric adenocarcinoma of fundic gland type (GAFG) is classified into pure GAFG and gastric adenocarcinoma of fundic gland mucosal type (GAFGM) which exhibited differentiation toward gastric foveolar epithelium in addition to fundic gland differentiation, histopathologically. This histopathological classification of GAFG is useful to estimate its malignant potential. The comprehensive genetic analysis using next generation sequencing of GAFG identified that GAFG is a neoplasm with low-grade malignancy, and the frequent presence of GNAS mutation is a characteristic genetic feature of GAFG, both pure GAFG and GAFGM (GAFG: 21.4%, pure GAFG: 19.0%, GAFGM: 28.6%). We will verify the specificity of obtained oncogenic driver mutations and speculate the signaling pathway of carcinogenesis of GAFG.
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Report
(4 results)
Research Products
(15 results)