| Project/Area Number |
15K19064
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | Kurume University |
|---|
Principal Investigator |
Naito Yoshiki 久留米大学, 大学病院, 講師 (50465712)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 人体病理 / 肝胆道系腫瘍 / 胆管内乳頭状腫瘍 / 分子病理 / 診断病理学 |
|---|
| Outline of Final Research Achievements |
In this study, we investigated clinicopathological features, somatic mutation and aberrant expressions in 27 tumors of IPNBs. Macroscopically, there were no cystic types in the extra-IPNB (P<0.001). Immunohistochemically, MUC5AC was expressed in 9 tumors (90%, 9/10) in the intra-IPNB, but was expressed only in 7 tumors in extra-IPNB (41%, 7/17) (P<0.05). There were no differences in the somatic mutation (KRAS and PIK3CA) and aberrant expressions (P53 and P16) There were no significant differences in overall survival between intra-IPNB and extra-IPNB (P=0.899).
This study revealed that intra-IPNB and extra-IPNB present mostly the common clinicopathologic features and molecular analysis.
|
