Functional analysis of gangliosides in invasion front in early stage glioma
Project/Area Number |
15K19073
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Experimental pathology
|
Research Institution | Chubu University |
Principal Investigator |
OHKAWA Yuki 中部大学, 生命健康科学部, 研究員 (40723896)
|
Co-Investigator(Renkei-kenkyūsha) |
FURUKAWA Koichi 中部大学, 生命健康科学部, 教授 (80211530)
MOMOTA Hiroyuki 東京大学, 医科学研究所, 講師 (60469971)
NATSUME Atsushi 名古屋大学, 医学系研究科, 准教授 (30362255)
WAKABAYASHI Toshihiko 名古屋大学, 医学系研究科, 教授 (50220835)
|
Research Collaborator |
KATO Akira 名古屋大学, 医学系研究科, 研究員
HASHIMOTO Noboru 徳島大学, 医歯薬学研究部, 助教
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | ガングリオシド / グリオーマ / マウスモデル / EMARS |
Outline of Final Research Achievements |
Acidic glycosphingolipids, ganglioside GD3 and GD2 are expressed in gliomas strongly, while expression levels of them in normal brain tissues are minimal. In this study, we tried to clarify functions of GD3 and GD2 in invasion front in early stage of gliomas using gene-engineered murine glioma model. Results indicated that GD3 and GD2 enhanced invasion activity by inducing over-expression of matrixmetalloproteinase, Mmp9 via activation of a transcriptional factor Ap2α. These data suggest advantages to establish GD3- or GD2-targeted therapies for glioma patients.
|
Report
(3 results)
Research Products
(16 results)
-
-
-
-
-
[Journal Article] Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis.2016
Author(s)
Ohmi Y, Ise W, Harazono A, Takakura D, Fukuyama H, Baba Y, Narazaki M, Shoda H, Takahashi N, Ohkawa Y, Ji S, Sugiyama F, Fujio K, Kumanogoh A, Yamamoto K, Kawasaki N, Kurosaki T, Takahashi Y, Furukawa K.
-
Journal Title
Nature Communications
Volume: in press
Issue: 1
Pages: 11205-11205
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
[Journal Article] Expression analysis of 0-series gangliosides in human cancer cell lines with monoclonal antibodies generated using knockout mice of ganglioside synthase genes.2016
Author(s)
Bhuiyan RH, Kondo Y, Yamaguchi T, Tokuda N, Ohkawa Y, Hashimoto N, Ohmi Y, Yamauchi Y, Furukawa K, Okajima T, Furukawa K.
-
Journal Title
Glycobiology
Volume: in press
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Ganglioside GD3 enhances invasiveness via Yes activation by forming a complex of GD3/PDGFRα/Yes in gliomas2015
Author(s)
Yuki Ohkawa, Hiroyuki Momota, Akira Kato, Noboru Hashimoto, Yuhsuke Tsuda, Norihiro Kotani, Koichi Honke, Akio Suzumura, Keiko Furukawa, Yuhsuke Ohmi, Atsushi Natsume, Toshihiko Wakabayashi and *Furukawa K
-
Journal Title
J. Biol. Chem.
Volume: 290
Issue: 32
Pages: 16043-16058
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
[Journal Article] Ganglioside GD3 Enhances Invasiveness of Gliomas by Forming a Complex with Platelet-derived Growth Factor Receptor α and Yes Kinase.2015
Author(s)
Ohkawa Y, Momota H, Kato A, Hashimoto N, Tsuda Y, Kotani N, Honke K, Suzumura A, Furukawa K, Ohmi Y, Natsume A, Wakabayashi T, Furukawa K.
-
Journal Title
J Biol Chem.
Volume: 290
Issue: 26
Pages: 16043-16058
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
[Presentation] Loss of b-series gangliosides attenuates glioma development and expansion.2016
Author(s)
Ohkawa Y, Momota H, Kato A, Esaki N, Chou B, Takano M, Bhuiyan RH, Furukawa K, Natsume A, Wakabayashi T, Furukawa K.
Organizer
The 3rd International Symposium on Glycol-Neuroscience
Place of Presentation
淡路夢舞台国際会議場、兵庫県淡路市
Year and Date
2016-01-14
Related Report
Int'l Joint Research
-
-
-