Exploration study on gene therapeutic targets and biomarkers for early diagnosis using an impaired glucose tolerance zebrafish model
Project/Area Number |
15K19074
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Experimental pathology
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Research Institution | Mie University |
Principal Investigator |
Zang Liqing 三重大学, 地域イノベーション学研究科, 助教 (10437105)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 2型糖尿病 / ゼブラフィッシュ / 遺伝子抑制 / 治療標的遺伝子 / 耐糖能異常 / 肥満モデル / 遺伝子発現抑制 / CRISPR-Cas9システム |
Outline of Final Research Achievements |
Impaired glucose tolerance is a pre-diabetic state of type 2 diabetes mellitus (T2DM) that is associated with either insulin resistance, low insulin production or both. Early detection and therapeutic treatment of impaired glucose tolerance is now attracting attention as a prophylactic treatment strategy. In this study, we developed a T2DM model zebrafish and identified novel therapeutic targets gene (such as hmox1) by RNA-seq analysis. Knockdown study of these genes ameliorated the T2DM phenotypes including glucose intolerance.
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Report
(3 results)
Research Products
(13 results)