Why does atopic dermatitis often relapse in the same skin region?

• Project/Area Number: 15K19076
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: Tottori University
• Principal Investigator: Murata Akihiko 鳥取大学, 医学部, 助教 (90624221)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: アトピー性皮膚炎 / 接触性皮膚炎 / 組織常在性記憶T細胞 / 皮膚局所の免疫記憶 / 皮膚炎 / CD4+ T細胞 / CD8+ T細胞 / 表皮ｇamma-delta T細胞 / マスト細胞 / gamma-delta T細胞

Outline of Final Research Achievements

The reason why atopic dermatitis often relapses in the same skin region is unclear. By using a mouse model, we found that the skin that had experienced inflammation and cured showed an accelerated inflammatory response upon reexposure to the same antigen. This 'local skin memory (LSM)' response involved tissue resident memory T cells (TRM cells) that remained in the inflammation-experienced skin for a long time. Analyses of the antigen-reexposed skin showed that the initiation of the LSM response involved inflammatory cytokines including interferon γ secreated from the activated TRM cells. Thus, these results suggest that the removal of TRM cells from the inflammation-experienced skin region will be needed to prevent the relapsing of atopic dermatitis.

Research Products

• [Journal Article] Correlation between cell aggregation and antibody production in IgE-producing plasma cells. (2017)
  • Author(s): Hikosaka, M., Murata, A., Yoshino, M., and Hayashi, S.I.
  • Journal Title: Biochemistry and Biophysics Reports Volume: in press Pages: 224-231
  • DOI: 10.1016/j.bbrep.2017.04.007
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Notch-mediated cell adhesion (2016)
  • Author(s): Akihiko Murata, Shin-Ichi Hayashi
  • Journal Title: Biology(Basel) Volume: 5 Issue: 1 Pages: 5-5
  • DOI: 10.3390/biology5010005
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 抗原特異的細胞の凝集によるＩｇＥ産生制御 (2016)
  • Author(s): 彦坂茉里、村田暁彦、吉野三也、林眞一
  • Journal Title: 臨床免疫・アレルギー科 Volume: 65 Pages: 334-339
• [Presentation] Local skin memory response in contact dermatitis involves tissue resident memory T cells (2017)
  • Author(s): Akihiko Murata, Miya Yoshino, Shin-Ichi Hayashi
  • Organizer: 第46回日本免疫学会総会・学術集会
• [Presentation] Measurement of the transport of skin self-antigens under inflammatory conditions (2017)
  • Author(s): Miya Yoshino, Kaori Suekane, Ai Suzuki, Naoto Honda, Kazune Tanigawa, Akihiko Murata, Shin-Ichi Hayashi
  • Organizer: 第46回日本免疫学会総会・学術集会
• [Presentation] C57BL/6 mice lack the local skin memory formation by contact dermatitis (2016)
  • Author(s): Akihiko Murata, Miya Yoshino, Mari Hikosaka, Shin-Ichi Hayashi
  • Organizer: 第45回日本免疫学会総会・学術集会
  • Place of Presentation: 沖縄コンベンションセンター(沖縄県、宜野湾市)
  • Year and Date: 2016-12-05
• [Presentation] Enhancement of antibody production in IgE producing cells requires cell aggregation via Fc gamma-receptors (2016)
  • Author(s): Mari Hikosaka, Akihiko Murata, Miya Yoshino, Shin-Ichi Hayashi
  • Organizer: 第45回日本免疫学会総会・学術集会
  • Place of Presentation: 沖縄コンベンションセンター(沖縄県、宜野湾市)
  • Year and Date: 2016-12-05
• [Presentation] Measurement of altered transport of skin self-antigens in the active state (2016)
  • Author(s): Miya Yoshino, Akihiko Murata, Mari Hikosaka, Shin-Ichi Hayashi
  • Organizer: 第45回日本免疫学会総会・学術集会
  • Place of Presentation: 沖縄コンベンションセンター(沖縄県、宜野湾市)
  • Year and Date: 2016-12-05
• [Presentation] Intensity of local skin memory response varying with the type of locally persisting T cell subsets (2016)
  • Author(s): Akihiko Murata
  • Organizer: 16th International Congress of Immunology
  • Place of Presentation: Melbourne Convention and Exibition Centre(Melbourne, Australia)
  • Year and Date: 2016-08-21
  • Int'l Joint Research
• [Presentation] Mast cells are dispensable for the local skin memory response (2015)
  • Author(s): Akihiko Murata, Miya Yoshino, Mari Hikosaka, Shin-Ichi Hayashi
  • Organizer: 第44回日本免疫学会総会・学術集会
  • Place of Presentation: 札幌コンベンションセンター(北海道、札幌市)
  • Year and Date: 2015-11-18
• [Presentation] Analysis of the transport of skin self-antigens in Pynod-Ccr7-double knockout mice (2015)
  • Author(s): Miya Yoshino, Akihiko Murata, Mari Hikosaka, Shin-Ichi Hayashi
  • Organizer: 第44回日本免疫学会総会・学術集会
  • Place of Presentation: 札幌コンベンションセンター(北海道、札幌市)
  • Year and Date: 2015-11-18
• [Presentation] Antigen-mediated cell aggregation in IgE-producing cells (2015)
  • Author(s): Mari Hikosaka, Akihiko Murata, Yuhki Shimoda, Miya Yoshino, Shin-Ichi Hayashi
  • Organizer: 第44回日本免疫学会総会・学術集会
  • Place of Presentation: 札幌コンベンションセンター(北海道、札幌市)
  • Year and Date: 2015-11-18
• [Remarks] 鳥取大学医学部生命科学科分子細胞生物学講座免疫学分野ホームページ 業績
  • URL: http://www.med.tottori-u.ac.jp/immunol/307/1371.html
• [Remarks] 鳥取大学医学部生命科ホームページ 過去のお知らせ
  • URL: http://www.med.tottori-u.ac.jp/introduction/faculty/873/921/