| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Outline of Final Research Achievements |
The reason why atopic dermatitis often relapses in the same skin region is unclear. By using a mouse model, we found that the skin that had experienced inflammation and cured showed an accelerated inflammatory response upon reexposure to the same antigen. This 'local skin memory (LSM)' response involved tissue resident memory T cells (TRM cells) that remained in the inflammation-experienced skin for a long time. Analyses of the antigen-reexposed skin showed that the initiation of the LSM response involved inflammatory cytokines including interferon γ secreated from the activated TRM cells. Thus, these results suggest that the removal of TRM cells from the inflammation-experienced skin region will be needed to prevent the relapsing of atopic dermatitis.
|
