Role of PKM2 in gastric anc pancreatic cancer, as a regulator of cancer metabolism

• Project/Area Number: 15K19080
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: Yokoyama Misa 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 共同研究員 (90727471)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: PKM2 / 胃癌 / 膵癌 / PKM

Outline of Final Research Achievements

To elucidate the role of PKM2 in the development of gastric and cancer development, we evaluated molecular mechanisms of PKM2 using clinical tissue sample and cancer cell lines. We demonstrated that PKM2 plays critical roles of cell growth in gastric and pancreatic cancer. These data suggested that PKM2 is a good target for therapy.

Research Products

• [Journal Article] Enhanced expression of PKM2 is involved in the gastric cancer development via regulating cancer specific metabolism. (2017)
  • Author(s): Shiroki T, Yokoyama M, Tanuma N, Maejima R, Tamai K, Yamaguchi K, Oikawa T, Noguchi T, Miura K, Fujiya T, Shima H, Sato I, Kamiya N, Hatakeyama M, Iijima K, Shimosegawa T and Satoh K.
  • Journal Title: Cancer Science Volume: 印刷中 Issue: 5 Pages: 931-940
  • DOI: 10.1111/cas.13211
  • Peer Reviewed / Open Access
• [Presentation] ピルビン酸キナーゼM2(PKM2)と膵癌細胞増殖 (2016)
  • Author(s): 横山 美沙, 渋谷 莉恵, 坂本 良美, 田沼 延公, 玉井 恵一, 田中 伸幸, 山口 壹範, 菅村 和夫, 佐藤 賢一
  • Organizer: 日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-11-30
• [Presentation] ピルビン酸キナーゼM2(PKM2)と膵癌細胞増殖 (2016)
  • Author(s): 1)横山 美沙, 渋谷 莉恵, 坂本 良美, 田沼 延公, 望月 麻衣, 中村 真央, 玉井 恵一, 山口 壹範, 田中 伸幸, 菅村 和夫, 佐藤 賢一
  • Organizer: 日本膵臓学会大会
  • Place of Presentation: 仙台
  • Year and Date: 2016-08-04
• [Presentation] ピルビン酸キナーゼM2(PKM2)と膵癌細胞増殖 (2015)
  • Author(s): 横山美沙ほか
  • Organizer: 第38回分子生物学会年会、第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01