Research Project
Grant-in-Aid for Young Scientists (B)
Using a 2-stage skin carcinogenesis model, we found that a single DMBA application was sufficient to produce papillomas in Protein phosphatase 6 catalytic subunit (Ppp6c)-deficient skin. The data suggests that Ppp6c-deficient skin is predisposed to carcinogenesis initiated by DMBA. Ppp6c-deficient skin tissues show an enhanced inflammatory response following DMBA treatment. Ppp6c-deficient tissue samples exhibited thicker epidermis associated with hyperkeratosis, cellular infiltration of the dermis, and disappearance of subcutaneous fat tissue, indicating inflammatory and proliferative responses. Expression of inflammation-related genes is upregulated by DMBA treatment and that this effect that is more significant in Ppp6c-deficient skin. Molecular mechanism underlying its pathogenesis is thought to be that TNF-α- and IL-1β-dependent NF-kB signaling is enhanced in Ppp6c-deficient keratinocytes.
All 2016 2015
All Journal Article (2 results) (of which Peer Reviewed: 2 results, Acknowledgement Compliant: 2 results, Open Access: 1 results) Presentation (4 results)
Oncogene
Volume: 印刷中 Issue: 35 Pages: 4647-55
10.1038/onc.2014.398
Cancer Lett.
Volume: 365 Issue: 2 Pages: 223-228
10.1016/j.canlet.2015.05.022