The mechanism of complement-inhibitory function in larval stage of Echinococcus multilocularis
| Project/Area Number |
15K19083
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
Mizuki Sasaki 旭川医科大学, 医学部, 助教 (00632126)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 多包虫症 / 補体 / 多包虫 / 寄生虫 / エキノコックス / 条虫 |
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| Outline of Final Research Achievements |
Alveolar echinococcosis (AE) is a zoonotic infectious disease caused by the larval stage of the cestode Echinococcus multilocularis. In humans, metacestodes develop asexually like a tumor, mainly in the liver. I identified new genes of the serpin family (serpin) in E. multilocularis using genome and gene data sets, and attempted to determine their functions as inhibitor of complement cascade. As a result, all of three serpins did not show the complement-inhibitory activity. However, I demonstrated the secretion of these gene products from larval stage of E. multilocularis and protein expression in the germinal layer the parasite.
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Report
(4 results)
Research Products
(11 results)
