| Project/Area Number |
15K19085
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Research Collaborator |
YOKOTA Natsuki 杏林大学, 医学部, 実験助手
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | γδT細胞 / マラリア / 免疫記憶 / γδ T細胞 |
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| Outline of Final Research Achievements |
Immunological memory is a crucial phenomenon for protective immunity against a variety of pathogens. However, it remains largely unknown the mechanism how immunological memory against malaria develops and maintains during malaria. Thus, to elucidate the mechanism, we used mice model of malaria. We have shown that gamma delta T cells, which is a innate-like lymphocyte, have crucial functions for protective immunity against malaria during primary infection with Plasmodium parasites. In this study, we suggest that gamma delta T cell would be involved in immunological memory against malaria.
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