Elucidation whether innate-like lymphocytes are related with immunological memory during malaria
Project/Area Number |
15K19085
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Parasitology (including sanitary zoology)
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Research Institution | Kyorin University |
Principal Investigator |
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Research Collaborator |
YOKOTA Natsuki 杏林大学, 医学部, 実験助手
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | γδT細胞 / マラリア / 免疫記憶 / γδ T細胞 |
Outline of Final Research Achievements |
Immunological memory is a crucial phenomenon for protective immunity against a variety of pathogens. However, it remains largely unknown the mechanism how immunological memory against malaria develops and maintains during malaria. Thus, to elucidate the mechanism, we used mice model of malaria. We have shown that gamma delta T cells, which is a innate-like lymphocyte, have crucial functions for protective immunity against malaria during primary infection with Plasmodium parasites. In this study, we suggest that gamma delta T cell would be involved in immunological memory against malaria.
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Report
(4 results)
Research Products
(45 results)
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[Presentation] Plasmodium falciparum ガメトサイト形成に伴って特異的に発現される分子の網羅的解析.2016
Author(s)
朝日博子, 救仁郷圭祐, 竹田美香, 矢幡一英, 井上信一, 新倉 保, Indah S. Tantular, Fumihiko Kawamoto, 中澤秀介, 小林富美惠, 金子 修, 鈴木 穣
Organizer
第85回日本寄生虫学会大会
Place of Presentation
宮崎
Year and Date
2016-03-19
Related Report
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[Presentation] IL-17A/F遺伝子欠損マウスは長期喫煙曝露による気腔開大が抑制される2015
Author(s)
中村 益夫, 和田 裕雄, 佐田 充, 乾 俊哉, 中本 啓太郎, 檜垣 学, 宮東 昭彦, 井上 信一, 花輪 智子, 小林 富美恵, 菅間 博, 滝澤 始
Organizer
第38回日本分子生物学会年会/第88回日本生化学会大会
Place of Presentation
神戸
Year and Date
2015-12-01
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