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Molecular analysis of the microbial substitution of Staphylococcus aureus and Pseudomonas aeruginosa

Research Project

Project/Area Number 15K19094
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Bacteriology (including mycology)
Research InstitutionHiroshima University

Principal Investigator

Kayama Shizuo  広島大学, 医歯薬保健学研究院(歯), 助教 (50432761)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords日和見感染症 / 緑膿菌 / 黄色ブドウ球菌 / 混合感染 / ランダム変異 / 菌交代現象 / トランスポゾン変異株
Outline of Final Research Achievements

In order to find the resistant facters of Staphylococcus aureus against Pseudomonas aeruginosa, we made transposon mutagenesis library of community-acquired S. aureus, TY825. We found 16 candidate genes that might be related to the resistance facter against P. aeruginosa.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Inhibitory effects of antibiofilm compound 1 against Staphylococcus aureus biofilms.2016

    • Author(s)
      Shrestha L, Kayama S, Sasaki M, Kato F, Hisatsune J, Tsuruda K, Koizumi K, Tatsukawa N, Yu L, Takeda K, Sugai M.
    • Journal Title

      Microbiology and Immunology

      Volume: 60 Issue: 3 Pages: 148-159

    • DOI

      10.1111/1348-0421.12359

    • NAID

      40020779260

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Persistence and Epidemic Propagation of a Pseudomonas aeruginosa Sequence Type 235 Clone Harboring an IS26 Composite Transposon Carrying the blaIMP-1 Integron in Hiroshima, Japan, 2005 to 20122015

    • Author(s)
      Wataru Shimizu, Shizuo Kayama, Shuntaro Kouda, Yoshitoshi Ogura, Kanao Kobayashi, Norifumi Shigemoto, Norimitsu Shimada, Raita Yano, Junzo Hisatsune, Fuminori Kato, Tetsuya Hayashi, Taijiro Sueda, Hiroki Ohge, and Motoyuki Sugai
    • Journal Title

      Antimicrobial Agents and Chemotherapy

      Volume: 59 Issue: 5 Pages: 2678-2687

    • DOI

      10.1128/aac.04207-14

    • Related Report
      2015 Research-status Report
    • Peer Reviewed

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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