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Involvement and activation mechanism of novel PAMPs in lung mycoses

Research Project

Project/Area Number 15K19098
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Bacteriology (including mycology)
Research InstitutionTokyo University of Pharmacy and Life Science

Principal Investigator

Ishibashi Ken-ichi  東京薬科大学, 薬学部, 講師 (20453805)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords病原真菌 / アスペルギルス / PAMPs / 感染防御 / 真菌PAMPs / α-1,3-グルカン / 真菌細胞壁多糖 / 細胞壁多糖 / グルカン
Outline of Final Research Achievements

Aspergillus is a medically important fungal genus that can cause a life-threatening infection called aspergillosis in immunocompromised patients. The α-1,3-glucan is the one of main components of Aspergillus cell wall. However, the immunological activity of α-1,3-glucan is not fully characterized. In this study, we prepared soluble and insoluble Aspergillus cell wall α-1,3-glucanand examined the immunological activity.
The Aspergillus cell wall insoluble and soluble α-1,3-glucan (AspAG and ASAG) was prepared from acetone-dried mycerium. AspAG induced inflammatory cytokine production in a dose-dependent manner, but ASAG did not in vitro. AspAG induced inflammatory response such as increased vascular permeability and priming effect to PAMPs in vivo. Anti-ASAG antibody was detected in the serum of each human volunteer. From these findings, Aspergillus cell wall α-1,3-glucan is important molecule in the pathology of Aspergillus related infectious diseases.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 2015

All Presentation (8 results)

  • [Presentation] Aspergillus fumigatus細胞壁α‐1,3‐glucanの細胞活性の検討2017

    • Author(s)
      佐藤恵理子,石橋健一,山中大輔,安達禎之,大野尚仁
    • Organizer
      日本薬学会 第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Aspergillus細胞壁α-1,3-glucan投与マウスの炎症反応誘発作用の検討2017

    • Author(s)
      中嶋 唯,石橋 健一, 山中 大輔, 安達 禎之, 大野 尚仁
    • Organizer
      日本薬学会 第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Preparation and immunological characterization of Aspergillus α-1,3-glucan2016

    • Author(s)
      Ken-ichi Ishibashi, Yusuke Nishimura, Ayumi Mizukami, Chiho Yanai, Daisuke Yamanaka, Yoshiyuki Adachi, Naohito Ohno
    • Organizer
      BSI / NVVI Congress 2016
    • Place of Presentation
      Liverpool UK
    • Year and Date
      2016-12-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Aspergillus細胞壁不溶性及び可溶性α-1,3-glucan刺激による サイトカイン産生の検討2016

    • Author(s)
      西村祐亮,石橋健一,山中大輔,安達禎之,大野尚仁
    • Organizer
      第60回日本医真菌学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-10-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] Aspergillus細胞壁不溶性及び可溶性α-1,3-glucanの調製と生物活性2016

    • Author(s)
      西村祐亮, 石橋健一,柳井千穂,山中大輔,安達禎之,大野尚仁
    • Organizer
      第37回関東医真菌懇話会
    • Place of Presentation
      東京
    • Year and Date
      2016-06-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] アスペルギルス細胞壁α-1,3-グルカンの精製とその物性及び生物活性の検討2016

    • Author(s)
      西村祐亮,石橋健一,柳井千穂,山中大輔,安達禎之,大野尚仁
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] アスペルギルス細胞壁α-1,3-グルカンの調製と生物活性の検討2016

    • Author(s)
      石橋健一,西村祐亮,水上亜友美,柳井千穂,山中大輔,安達禎之,大野尚仁
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター
    • Year and Date
      2016-03-23
    • Related Report
      2015 Research-status Report
  • [Presentation] Aspergillus細胞壁α-1,3-グルカン抗体の反応性2015

    • Author(s)
      水上亜友美,石橋健一,山中大輔,安達禎之,大野尚仁
    • Organizer
      第59回日本医真菌学会総会・学術集会
    • Place of Presentation
      ホテル さっぽろ文芸館
    • Year and Date
      2015-10-09
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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