Analysis of a host kinase for multiplication and oncopathogenesis of hepatitis C virus
Project/Area Number |
15K19106
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Virology
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Research Institution | The University of Tokyo |
Principal Investigator |
Goto Kaku 東京大学, 医科学研究所, 特任研究員 (80523513)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | Kinase / HCV / HCC / Drug / Phosphorylation / Carcinogenesis |
Outline of Final Research Achievements |
New strategies against hepatitis C virus (HCV) and hepatocellular carcinoma (HCC) were developed, targeting the kinase identified to be a host cellular factor for the viral replication and pathogenesis. An anti-alcoholism drug, the top hit in our in vitro screen for inhibitors of the kinase using a Food and Drug Administration-approved drug library, was investigated. We reported the modes of inhibition indicated by the chemical kinetics and structures, and the suppression of fibrotic signaling, HCC cell proliferation, and HCV replication in the international journal.
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Report
(3 results)
Research Products
(3 results)